Title:
１５β－ヒドロキシ－酢酸オサテロンの結晶多形
Document Type and Number:
Japanese Patent JP7241807
Kind Code:
B2
Abstract:
Provided is a crystalline polymorphic form A of 15²-hydroxy-osaterone acetate having an improved stability (storage stability, pulverization stability, and absorption characteristics). In a powder X-ray diffraction spectrum, characteristic diffraction peaks of the crystalline polymorphic form A of 15²-hydroxy-osaterone acetate appear at diffraction angles 2¸ of 9.6° ± 0.2°, 17.1° ± 0.2°, and 20.2° ± 0.2°. The crystalline polymorphic form A has a melting point of 280 to 283°C and is a prism crystal.
Inventors:
Takayoshi Nakagawa
Hiroyuki Hayashi
Koichi Miyazaki
Shigeki Iwashita
Hiroyuki Hayashi
Koichi Miyazaki
Shigeki Iwashita
Application Number:
JP2021094176A
Publication Date:
March 17, 2023
Filing Date:
June 04, 2021
Export Citation:
Assignee:
Aska Pharmaceutical Co., Ltd.
International Classes:
C07J73/00
Domestic Patent References:
| JP2591640B2 |
Foreign References:
| WO2017195804A1 |
Other References:
Chem. Pharm. Bull.,1993, Vol.41, No.5,p.870-875
Organic Process Research & Development,2009, Vol.13, No.6,p.1241-1253
Journal of Pharmaceutical Sciences,1979, Vol.68, No.2,p.175-177
Organic Process Research & Development,2009, Vol.13, No.6,p.1241-1253
Journal of Pharmaceutical Sciences,1979, Vol.68, No.2,p.175-177
Attorney, Agent or Firm:
Hiroshi Sakanaka
Mitsuo Hokita
Mitsuo Hokita
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