Title:
メサコニンの結晶形およびその調製方法
Document Type and Number:
Japanese Patent JP7072674
Kind Code:
B2
Abstract:
The present invention relates to a method for preparing mesaconine and related intermediaries. Specifically, in the method for preparing mesaconine of the present invention, aconitine extracted from the Aconitum soongaricum Stapf. of aconitum plant is used as a raw material and subjected to alkalization, acetylation, N-de-ethylation, N-methylation, and hydrolysis to obtain mesaconine. The method for preparing mesaconine in the present invention is simple in operation, high in yield, environmentally friendly and pollution-free, and suitable for industrial production.
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Inventors:
Flying
Fukuno
Empress Ma
Akira Waka Ice
Fukuno
Empress Ma
Akira Waka Ice
Application Number:
JP2020562818A
Publication Date:
May 20, 2022
Filing Date:
January 23, 2019
Export Citation:
Assignee:
Good Doctor Pharmaceutical Group Company, Limited
International Classes:
C07D221/22; A61K31/439; A61P9/04
Other References:
Natural Product Communications,2012年,Vol.7, No.6, pp.713-720
"新医薬品の規格及び試験方法の設定について",医薬審発第568号,2001年05月01日
山野光久,医薬品のプロセス研究における結晶多形現象への取り組み,有機合成化学協会誌,2007年09月01日,Vol.65, No.9,p.907(69)-913(75)
大島寛,結晶多形・擬多形の析出挙動と制御,PHARM STAGE,2007年01月15日,Vol.6, No.10,p.48-53
薬学雑誌,1984年,Vol.104, No.7, pp.731-752
Journal of the American Chemical Society,1960年,Vol.82,No.19, pp.5182-5187
"新医薬品の規格及び試験方法の設定について",医薬審発第568号,2001年05月01日
山野光久,医薬品のプロセス研究における結晶多形現象への取り組み,有機合成化学協会誌,2007年09月01日,Vol.65, No.9,p.907(69)-913(75)
大島寛,結晶多形・擬多形の析出挙動と制御,PHARM STAGE,2007年01月15日,Vol.6, No.10,p.48-53
薬学雑誌,1984年,Vol.104, No.7, pp.731-752
Journal of the American Chemical Society,1960年,Vol.82,No.19, pp.5182-5187
Attorney, Agent or Firm:
Patent business corporation HARAKENZO WORLD PATENT & TRADEMARK