（２Ｒ，６Ｒ）－ヒドロキシノルケタミンおよび（２Ｓ，６Ｓ）－ヒドロキシノルケタミンの結晶形態および合成方法 - The United States of America, As Represented by The Secretary, Department of Health and Human Services

Title:

（２Ｒ，６Ｒ）－ヒドロキシノルケタミンおよび（２Ｓ，６Ｓ）－ヒドロキシノルケタミンの結晶形態および合成方法

Document Type and Number:

Japanese Patent JP7379567

Kind Code:

B2

Abstract:

The disclosure provides a method for synthesizing free base forms of (2R,6R)-hydroxynorketamine (HNK) and (2S,6S)-hydroxynorketamine. In an embodiment synthesis of (2R,6R)-hydroxynorketam-ine (HNK) includes preparation of (R)-norket-amine via chiral resolution from racemic norketamine via a chiral resolution with L-pyro-glutamic acid. The disclosure also provided crystal forms of the corresponding (2R,6R)-hydroxynorketamine (HNK) and (2S,6S)-hy-droxynorketamine hydrochloride salts.

Inventors:

Thomas Craig
Morris Patrick
Zarate Carlos
Moadel Ruin
Gould Todd
Zanos Panoz

Application Number:

JP2022041167A

Publication Date:

November 14, 2023

Filing Date:

March 16, 2022

Export Citation:

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Assignee:

The United States of America, As Represented by The Secretary, Department of Health and Human Services
The University of Maryland, Baltimore

International Classes:

C07C221/00; C07B57/00; C07C225/20; C07C269/06; C07C271/24

Domestic Patent References:

JP2015501302A

Other References:

J. Org. Chem. ,1984年,49,3305-3310
Tetrahedron,1990年,Vol.46,No.2,523-544
Org. Lett.,2012年,Vol.14, No.24,6374-6376

Attorney, Agent or Firm:

Patent Attorney Corporation YKI International Patent Office

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