Title:
カバジタキセルの結晶性無水和物形態、その調製方法ならびにその医薬組成物
Document Type and Number:
Japanese Patent JP6698803
Kind Code:
B2
Abstract:
The present invention relates to a new anhydrous crystalline form of Cabazitaxel of formula (I), designated as form H. A further object of the present invention is a processes for the preparation of the above mentioned form H by recrystallization of Cabazitaxel from a mixture of decanoyl- and octanoyl triglycerides or from glycerol trioctanoate. Form H of Cabazitaxel is useful for the preparation of Cabazitaxel, Cabazitaxel salts, and polymorphic forms thereof. It is also particularly useful as a medicament, especially for the treatment of cancers.
Inventors:
Fog, Walter
Chiselli, Danielle
Domenegini, Luca
Gambini, Andrea
Petter Longo, Federico
Chiselli, Danielle
Domenegini, Luca
Gambini, Andrea
Petter Longo, Federico
Application Number:
JP2018229594A
Publication Date:
May 27, 2020
Filing Date:
December 07, 2018
Export Citation:
Assignee:
Indena Esse Pia
International Classes:
C07D305/14; A61K31/337; A61P35/00
Domestic Patent References:
| JP2011509980A | ||||
| JP2010506932A |
Other References:
小嶌隆史,医薬品開発における結晶形選択の効率化を目指して,薬剤学,2008年 9月 1日,Vol.68, No.5,p.344-349
STAHLY,P.,医薬品の塩選択,結晶多形のスクリーニングの重要性について,薬剤学,2006年,Vol.66,No.6,p.435-439
芦澤一英 他,医薬品の多形現象と晶析の科学,日本,丸善プラネット株式会社,2002年 9月20日,p.3-16
STAHLY,P.,医薬品の塩選択,結晶多形のスクリーニングの重要性について,薬剤学,2006年,Vol.66,No.6,p.435-439
芦澤一英 他,医薬品の多形現象と晶析の科学,日本,丸善プラネット株式会社,2002年 9月20日,p.3-16
Attorney, Agent or Firm:
Akio Miyazaki
Masaaki Ogata
Masaaki Ogata