アミノ脂質の結晶形態

Title:

アミノ脂質の結晶形態

Document Type and Number:

Japanese Patent JP7220154

Kind Code:

B2

Abstract:

Provided herein are novel solid forms of each of four compounds: (1) heptadecan-9-yl 8-((2-hydroxyethyl)amino)octanoate (“Compound 1”), (2) heptadecan-9-yl 8-((2-hydroxyethyl)(6-oxo-6-(undecyloxy)hexyl)amino)octanoate (“Compound 2”), (3) heptadecan-9-yl 8-((2-hydroxyethyl)(8-(nonyloxy)-8-oxooctyl)amino)octanoate (“Compound 3”), and (6Z,9Z,28Z,31Z)-heptatriaconta-6,9,28,31-tetraen-19-yl 4-(dimethylamino)butanoate (“MC3”), and related compositions and methods.

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Inventors:

Armerson, Orn
Chun, Eugene

Application Number:

JP2019550619A

Publication Date:

February 09, 2023

Filing Date:

March 15, 2018

Export Citation:

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Assignee:

ModernaTX,Inc.

International Classes:

C07C229/12; A61K31/7088; A61K47/18; A61K48/00; C07C59/225; C07C63/307; C07C65/03; C07C69/773; C07C309/04

Domestic Patent References:

JP2012526134A
JP2012530059A
JP2013545727A
JP2016525146A

Foreign References:

WO2016176330A1

Other References:

Journal of Pharmaceutical Sciences,1977年,Vol.66, No.1,p.1-19

Attorney, Agent or Firm:

Makoto Onda
Hironobu Onda
Atsushi Honda
Nakamura Miki

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