Title:
CRYSTALLINE FORMS OF N-(4-(4-(CYCLOPROPYLMETHYL)PIPERAZINE-1-CARBONYL)PHENYL)QUINOLINE-8-SULFONAMIDE
Document Type and Number:
Japanese Patent JP2023093762
Kind Code:
A
Abstract:
To provide crystalline forms.SOLUTION: Provided herein are amorphous and crystalline hemisulfate forms of the formula (I). Also provided are pharmaceutical compositions comprising the amorphous and crystalline hemisulfate forms, methods for manufacture thereof, and uses thereof for treating conditions associated with pyruvate kinase such as pyruvate kinase deficiency. In some embodiments, the crystalline form is crystalline form A characterized by X-ray powder diffraction peaks at 2Θ angles (±0.2°) of 9.9°, 15.8° and 22.6°.SELECTED DRAWING: Figure 1
Inventors:
JACOB P SIZEMORE
GUO LITING
MAHMOUD MIRMEHRABI
SU YEQING
SHIJAY CHANG
ERIK SIMON
JEFFREY D WILSON
JOSE LUIS RIOS LIZARRAGA
GUO LITING
MAHMOUD MIRMEHRABI
SU YEQING
SHIJAY CHANG
ERIK SIMON
JEFFREY D WILSON
JOSE LUIS RIOS LIZARRAGA
Application Number:
JP2023076364A
Publication Date:
July 04, 2023
Filing Date:
May 02, 2023
Export Citation:
Assignee:
AGIOS PHARMACEUTICALS INC
International Classes:
C07D215/36; A61K9/20; A61K31/496; A61K47/14; A61K47/26; A61K47/38; A61K49/00; A61P7/06; A61P43/00
Attorney, Agent or Firm:
Shusaku Yamamoto
Natsuki Morishita
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto
Natsuki Morishita
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto
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