Title:
エスシタロプラムオキサレートを含む結晶質調合物
Document Type and Number:
Japanese Patent JP2007526262
Kind Code:
A
Abstract:
The present invention discloses crystalline particles of escitalopram oxalate which either have a broad particle size distribution or comprise at least 0.01 % (w/w) of Z-4-(4-dimethylamino-1-(4-fluorophenyl)-but-1-enyl)-3-hydroxymethyl-benzonitrile, said particles being suitable for use in direct compression. Furthermore, the invention discloses a novel pharmaceutical unit dosage form containing such crystalline particles of escitalopram oxalate as well as methods for manufacture of such crystalline particles of escitalopram oxalate. Finally, the invention provides a method for reduction of the amount of hydroxyl containing impurities in a solution of citalopram or escitalopram.
Inventors:
Jensen Kim Voisthorp
Fumbure Ricke Eva
Lily kuren ken
Kristensen Troelus Volskar
Fumbure Ricke Eva
Lily kuren ken
Kristensen Troelus Volskar
Application Number:
JP2007501117A
Publication Date:
September 13, 2007
Filing Date:
February 21, 2005
Export Citation:
Assignee:
Her Lundbeck Actiezer Scabet
International Classes:
A61K31/343; A61K9/14; A61K9/20; A61K9/30; A61K9/48; A61K31/34; A61K47/04; A61K47/10; A61K47/12; A61K47/26; A61K47/36; A61K47/38; A61K47/44; A61P25/24; C07B63/00; C07D307/87
Domestic Patent References:
| JP2004527551A | 2004-09-09 | |||
| JP2005535322A | 2005-11-24 | |||
| JP2006514952A | 2006-05-18 | |||
| JPH0236177A | 1990-02-06 |
Foreign References:
| WO2004085416A1 | 2004-10-07 | |||
| WO2003000672A1 | 2003-01-03 | |||
| WO2003011278A1 | 2003-02-13 |
Attorney, Agent or Firm:
Mitsufumi Esaki
Okumura Yoshimichi
Blacksmith
Okumura Yoshimichi
Blacksmith