Title:
結晶性微粉化粒子
Document Type and Number:
Japanese Patent JP5564943
Kind Code:
B2
Abstract:
Crystalline particles of N-(17-cyclopropylmethyl-4,5±-epoxy-3,14-dihydroxy-morphinan-6²-yl)-phthalimide or a pharmaceutically acceptable salt thereof are disclosed. The crystalline particles have a particle diameter distribution in which a particle diameter (D50) at the point where cumulative frequency of volume distribution cumulatively calculated from particles having a smaller diameter reaches 50% is within a range of 1 to 30 µm, and a particle diameter (D90) at the point where cumulative frequency of volume distribution cumulatively calculated from particles having a smaller diameter reaches 90% is not more than 90 µm, which crystalline particles have a degree of crystallinity of not less than 80%. By the crystalline particles, bioavailability of the active substance may be increased while ensuring storage stability of the compound.
Inventors:
Akimoto Masahiro
Komagata Toshikazu
Motoaki Shiraki
Akihiro Ando
Komagata Toshikazu
Motoaki Shiraki
Akihiro Ando
Application Number:
JP2009515238A
Publication Date:
August 06, 2014
Filing Date:
May 20, 2008
Export Citation:
Assignee:
TORAY INDUSTRIES,INC.
International Classes:
A61K31/485; A61K9/14; A61P13/10; A61P17/04; A61P25/04; C07D489/08
Domestic Patent References:
| JP2003073274A | 2003-03-12 | |||
| JP2006520765A | 2006-09-14 | |||
| JP2004511439A | 2004-04-15 |
Foreign References:
| WO2006049248A1 | 2006-05-11 | |||
| WO2005094826A1 | 2005-10-13 | |||
| WO2007055184A1 | 2007-05-18 | |||
| WO2000000492A1 | 2000-01-06 |
Other References:
JPN6008040877; 佐川良寿: 医薬品製剤技術 , 20020725, ｐ．５-１０，２５-３４, 株式会社シーエムシー出版
Attorney, Agent or Firm:
Patent Service Corporation Tanigawa International Patent Office