Title:
５−ヒドロキシ−１Ｈ−イミダゾール−４−カルボキサミド・３／４水和物の結晶及びその製造方法
Document Type and Number:
Japanese Patent JP5726830
Kind Code:
B2
Abstract:
PROBLEM TO BE SOLVED: To provide a method for producing 5-hydroxy-1H-imidazole-4-carboxamide having few impurities and excellent in storage stability.SOLUTION: A method for producing 5-hydroxy-1H-imidazole-4-carboxamide 3/4 hydrate comprises: a step where 2-amino malonamide is reacted with a compound represented by general formula (1) (wherein each R independently represents a Calkyl group) in the presence of a carboxylic acid so as to obtain 5-hydroxy-1H-imidazole-4-carboxamide; a step where the thus-obtained 5-hydroxy-1H-imidazole-4-carboxamide is reacted with an acidic compound so as to obtain an acidic salt of 5-hydroxy-1H-imidazole-4-carboxamide or a hydrate thereof; and a step where the thus-obtained acidic salt of 5-hydroxy-1H-imidazole-4-carboxamide or a hydrate thereof is reacted with a salt in the presence of an acidic solvent.
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Inventors:
Yasunori Fujimoto
Tomohiro Hashimoto
Katsuyuki Hayashi
Tomohiro Hashimoto
Katsuyuki Hayashi
Application Number:
JP2012218257A
Publication Date:
June 03, 2015
Filing Date:
September 28, 2012
Export Citation:
Assignee:
FUJIFILM Corporation
International Classes:
C07D233/90
Domestic Patent References:
| JP58024569A | ||||
| JP60185727A | ||||
| JP56025165A | ||||
| JP59170075A |
Foreign References:
| WO2009035168A1 |
Attorney, Agent or Firm:
Atsushi Nakajima
Kato Kazunori
Hiroshi Fukuda
Kato Kazunori
Hiroshi Fukuda