Title:
ベンゾオキサジアゾール誘導体の結晶
Document Type and Number:
Japanese Patent JP5077232
Kind Code:
B2
Abstract:
Object Provided are ²-form crystal, ³-form crystal, and ±-form crystal of a benzoxadiazole derivative, wherein a uniform crystal having sufficient qualities can be obtained with high reproducibility, and they can be anytime supplied as crystals of drug substance for use in producing pharmaceuticals, are particularly suitable for mass synthesis in industrial production, hardly exhibit hygroscopicity and have particularly excellent photo-resistance. Means for Resolution A solving means includes ²-form crystal of 4-[3-isopropyl-5-(6-phenyl-3-pyridyl)-4H-1,2,4-triazol-4-yl]-2,1,3-benzoxadiazole, which shows an endothermic peak at 145 to 150°C according to a differential scanning calorimeter analysis (DSC analysis) and shows X-ray powder diffraction peaks at 9.8, 11.1, 12.8, 13.3, 17.1, 20.2, 21.2 and 22.3 in 2¸(°), and the like. Selected Figure
Inventors:
Noritaka Hamada
Ryo Mizoguchi
Kuniyuki Sano
Sakida Uro
Yuji Awamura
Yu Iwakawa
Takahiko Tobe
Takashi Sugane
Ryo Mizoguchi
Kuniyuki Sano
Sakida Uro
Yuji Awamura
Yu Iwakawa
Takahiko Tobe
Takashi Sugane
Application Number:
JP2008524852A
Publication Date:
November 21, 2012
Filing Date:
July 13, 2007
Export Citation:
Assignee:
Astellas Pharma Inc.
International Classes:
C07D413/14; A61K31/4439; A61P25/18; A61P25/28; A61P43/00
Domestic Patent References:
| JP2004175788A | 2004-06-24 | |||
| JPH0741495A | 1995-02-10 |
Foreign References:
| WO2001087855A1 | 2001-11-22 |
Attorney, Agent or Firm:
Morita Taku
Emiko Yano
鈴木 ▲頼▼子
Hamai Kosuke
Emiko Yano
鈴木 ▲頼▼子
Hamai Kosuke