Title:
CURATIVE MEDICINE OR PREVENTIVE MEDICINE OF ARTICULAR RHEUMATISM
Document Type and Number:
Japanese Patent JP2012211086
Kind Code:
A
Abstract:
To provide a curative medicine or a preventive medicine of articular rheumatism having p38MAPK inhibitory activity and TNFα-production inhibitory activity accompanied by the p38MAPK inhibitory activity, and achieved in both a favorable in-vivo kinetics profile as a medicine and the reduction of hepatotoxicity.
There is provided the curative medicine or the preventive medicine of the articular rheumatism containing a 2,3-dihydro-1H-inden-2-yl urea derivative expressed by a formula (1), or a salt permitted in terms of pharmacology as an effective component.
Inventors:
MEGURO HIROYUKI
TAKAGAKI KOZUE
KAINO YOSHIE
MARUYAMA TATSUYA
SUZUKI HIRONAO
OKUMURA MAKOTO
TAKAGAKI KOZUE
KAINO YOSHIE
MARUYAMA TATSUYA
SUZUKI HIRONAO
OKUMURA MAKOTO
Application Number:
JP2011076160A
Publication Date:
November 01, 2012
Filing Date:
March 30, 2011
Export Citation:
Assignee:
TORAY INDUSTRIES
International Classes:
A61K31/17; A61K31/351; A61K31/40; A61K31/4453; A61K31/5375; A61K31/55; A61P19/02; A61P29/00; C07C275/34; C07C275/40; C07D295/12; C07D309/06
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