Title:
ＵＳＰ３０の阻害剤としての活性を有するシアノピロリジン誘導体
Document Type and Number:
Japanese Patent JP7084918
Kind Code:
B2
Abstract:
The present invention relates to a class of substituted-cyanopyrrolidines of Formula (I) with activity as inhibitors of deubiquitilating enzymes, in particular, ubiquitin C-terminal hydrolase 30 or ubiquitin specific peptidase 30 (USP30), having utility in a variety of therapeutic areas including cancer and conditions involving mitochondrial dysfunction.
Inventors:
Martin Lee Stockley
Mark Ian Kemp
Andrew Madin
Mark Ian Kemp
Andrew Madin
Application Number:
JP2019517227A
Publication Date:
June 15, 2022
Filing Date:
October 02, 2017
Export Citation:
Assignee:
Mission Therapeutics Limited
International Classes:
A61K31/407; A61K31/4184; A61K31/427; A61K31/4439; A61K31/5383; A61P3/00; A61P3/10; A61P9/00; A61P9/10; A61P21/00; A61P21/02; A61P25/00; A61P25/14; A61P25/16; A61P25/18; A61P25/28; A61P27/02; A61P35/00; A61P35/02; A61P43/00; C07D401/12; C07D403/12; C07D417/12; C07D471/04; C07D487/04; C07D498/04
Foreign References:
| WO2015061247A1 | ||||
| WO2016004272A1 | ||||
| WO2016065226A1 | ||||
| WO2016046530A1 | ||||
| WO2014041111A1 | ||||
| WO2015054555A1 | ||||
| WO2009129370A1 | ||||
| WO2001077073A1 |
Attorney, Agent or Firm:
Aoki Atsushi
Shinji Mihashi
Youichi Watanabe
Nakajima Masaru
Ryotaro Takei
Tatsunori Ikeda
Shinji Mihashi
Youichi Watanabe
Nakajima Masaru
Ryotaro Takei
Tatsunori Ikeda
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