Title:
ＴＮＦアルファの修飾因子として有用な環状化合物
Document Type and Number:
Japanese Patent JP6811233
Kind Code:
B2
Abstract:
Disclosed are compounds of Formula (I) or a salt thereof, wherein: Ring A is 3- to 6-membered carbocyclic or heterocyclic ring; X is CR1 or N; Y is —(CR5R5)m—; Z is —(CR5R5)n—; and q, R1, R2, R3, R4, R6, R7, R8, R9, and R10 are defined herein. Also disclosed are methods of using such compounds as modulators of TNFα, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.
Inventors:
Hi-Yoon Xiao
T. G. Murari Dar
Bin Jiang
Jinwoo Dwan
T. G. Murari Dar
Bin Jiang
Jinwoo Dwan
Application Number:
JP2018506125A
Publication Date:
January 13, 2021
Filing Date:
August 02, 2016
Export Citation:
Assignee:
BRISTOL-MYERS SQUIBB COMPANY
International Classes:
C07D487/04; A61K31/4188; A61K31/4439; A61K31/506; A61K31/5377; A61K31/541; A61P1/04; A61P11/06; A61P11/08; A61P13/12; A61P17/00; A61P17/06; A61P19/02; A61P19/06; A61P25/04; A61P29/00; A61P37/06; C07D487/14
Domestic Patent References:
| JP51049386A | ||||
| JP11228539A |
Foreign References:
| WO2015086525A1 |
Other References:
Database REGISTRY,2011年 9月,RN 1331912-71-0,Retrieved from STN international [online] ;retrieved on 12 June 2020
Attorney, Agent or Firm:
Samejima Mutsumi
Nagatoshi Shinagawa
Kure Hidenori
Kamahira Futami
Mizuhara Masahiro
Nagatoshi Shinagawa
Kure Hidenori
Kamahira Futami
Mizuhara Masahiro