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Title:
縮合環式基を有する環状ジアミン化合物
Document Type and Number:
Japanese Patent JP4225894
Kind Code:
B2
Abstract:
A cyclic diamine compound of formula (1): wherein R<1> and R<2> are individually a hydrogen atom or a methoxy group, provided R<1> is a methoxy group when R<2> is a hydrogen atom, or a hydrogen atom when R<2> is a methoxy group; A is an oxygen atom, a sulfur atom, CH=CH, CH=N or NR<3>, in which R<3> is a hydrogen atom, or a lower alkyl, hydroxy lower alkyl, lower alkoxy lower alkyl, aryl or aryl lower alkyl group; B is a nitrogen atom, CH or CR<4>, in which R<4> is a hydrogen atom, or a lower alkyl, hydroxy lower alkyl, lower alkoxy lower alkyl, aryl or aryl lower alkyl group; m is 1 or 2; and n is a number of 1 to 5, an acid-addition salt thereof, or a hydrate thereof. The compound has inhibitory effects on cell adhesion and is useful for treatment of allergy, asthma, rheumatism, arteriosclerosis, and inflammation.

Inventors:
Tatsuhiko Kodama
Masahiro Tamura
Toshiaki Oda
Yuko Yamazaki
Nishikawa Masahiro
Takeshi Toi
Yoshinori Kyotani
Application Number:
JP2003508715A
Publication Date:
February 18, 2009
Filing Date:
June 27, 2002
Export Citation:
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Assignee:
Kowa Co., Ltd.
International Classes:
C07D209/14; A61K31/4184; A61K31/423; A61K31/495; A61K31/496; A61K31/517; A61K31/551; A61K31/5513; A61P9/10; A61P11/06; A61P29/00; A61P37/08; A61P43/00; C07D215/12; C07D215/20; C07D235/14; C07D239/74; C07D243/06; C07D243/08; C07D263/56; C07D277/64; C07D295/08; C07D295/096; C07D307/81; C07D333/58; C07D401/14; C07D403/14; C07D405/14; C07D409/14; C07D413/14; C07D417/14; C07D235/10
Domestic Patent References:
JP9143075A
JP11092382A
Foreign References:
WO1998007702A1
Attorney, Agent or Firm:
Alga Patent Office, a patent business corporation
Miyuki Ariga
Toshio Takano
Toshio Nakajima
Asano Yasutaka
Hiromi Matoba
Masaki Murata
Hiroto Yamamoto



 
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