Title:
縮合環式基を有する環状ジアミン化合物
Document Type and Number:
Japanese Patent JP4225894
Kind Code:
B2
Abstract:
A cyclic diamine compound of formula (1): wherein R<1> and R<2> are individually a hydrogen atom or a methoxy group, provided R<1> is a methoxy group when R<2> is a hydrogen atom, or a hydrogen atom when R<2> is a methoxy group; A is an oxygen atom, a sulfur atom, CH=CH, CH=N or NR<3>, in which R<3> is a hydrogen atom, or a lower alkyl, hydroxy lower alkyl, lower alkoxy lower alkyl, aryl or aryl lower alkyl group; B is a nitrogen atom, CH or CR<4>, in which R<4> is a hydrogen atom, or a lower alkyl, hydroxy lower alkyl, lower alkoxy lower alkyl, aryl or aryl lower alkyl group; m is 1 or 2; and n is a number of 1 to 5, an acid-addition salt thereof, or a hydrate thereof. The compound has inhibitory effects on cell adhesion and is useful for treatment of allergy, asthma, rheumatism, arteriosclerosis, and inflammation.
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Inventors:
Tatsuhiko Kodama
Masahiro Tamura
Toshiaki Oda
Yuko Yamazaki
Nishikawa Masahiro
Takeshi Toi
Yoshinori Kyotani
Masahiro Tamura
Toshiaki Oda
Yuko Yamazaki
Nishikawa Masahiro
Takeshi Toi
Yoshinori Kyotani
Application Number:
JP2003508715A
Publication Date:
February 18, 2009
Filing Date:
June 27, 2002
Export Citation:
Assignee:
Kowa Co., Ltd.
International Classes:
C07D209/14; A61K31/4184; A61K31/423; A61K31/495; A61K31/496; A61K31/517; A61K31/551; A61K31/5513; A61P9/10; A61P11/06; A61P29/00; A61P37/08; A61P43/00; C07D215/12; C07D215/20; C07D235/14; C07D239/74; C07D243/06; C07D243/08; C07D263/56; C07D277/64; C07D295/08; C07D295/096; C07D307/81; C07D333/58; C07D401/14; C07D403/14; C07D405/14; C07D409/14; C07D413/14; C07D417/14; C07D235/10
Domestic Patent References:
JP9143075A | ||||
JP11092382A |
Foreign References:
WO1998007702A1 |
Attorney, Agent or Firm:
Alga Patent Office, a patent business corporation
Miyuki Ariga
Toshio Takano
Toshio Nakajima
Asano Yasutaka
Hiromi Matoba
Masaki Murata
Hiroto Yamamoto
Miyuki Ariga
Toshio Takano
Toshio Nakajima
Asano Yasutaka
Hiromi Matoba
Masaki Murata
Hiroto Yamamoto