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Title:
環状エーテル・アミド化合物。
Document Type and Number:
Japanese Patent JP5004075
Kind Code:
B2
Abstract:

To provide a new cyclic ether amide lipid constructing molecular aggregates by self-organization, and a lipid membrane forming a moderate intramolecular hydrogen bond.

This new cyclic ether amide lipid of 2 glycerol derivatives and 2 long chain alkyl compounds, having a diether bond backbone and an amide bond backbone simultaneously is obtained by synthesizing a diether lipid of a glycerol derivative building-in asymmetric groups and the long chain alkyl compound and then passing through a new intermediate material obtained by introducing an azide group having high reactivity. The obtained cyclic ether amide lipid is provided by forming the molecular aggregates by the self-organization, having a property close to that of a cyclic amide lipid and forming a lipid membrane having a somewhat weakened intramolecular hydrogen bond.

COPYRIGHT: (C)2008,JPO&INPIT


Inventors:
Shibagami Kisei
Shin Miyoshi
Application Number:
JP2006355091A
Publication Date:
August 22, 2012
Filing Date:
December 28, 2006
Export Citation:
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Assignee:
National Institute of Advanced Industrial Science and Technology
International Classes:
C07D273/08; C07C233/20; C07C247/04; C09K23/42; A61K47/22
Domestic Patent References:
JP2004196703A
JP2003286281A
JP2005060326A
JP2004075586A