PURPOSE: To prepare a novel compound inhibiting the angiotensinogen-cleaving action of renin.
CONSTITUTION: The compound has the formula I [wherein A is H, aryl or the like; B is -CH2-, the formula II (wherein R3 is H, 1-4C alkyl or the like; R11 is H, 1-4C alkyl; r is of from 0 to 2); D is a single bond, -NH-CO-NH- or the like; Z is -NH2, -OH or the like; W is -O-, -NR23 (wherein R23 is H, 1-4C alkyl); V is the formula III (Y is O, NH or the like; R5 is H, 1-4C alkyl or the like; R10 is H or OH; x and y are each 0 or 1; z is of from 0 to 4) or the like; R15 is 1-4C alkyl, aryl or the like; R1 is 1-4C alkyl, aryl or the like; n is 0 or 1; s is 0 or 1; t is of from 1 to 4]. For example, the compound is the formula IV (wherein A-B is the formula V, V is the formula VI). The compound of the formula I is produced by starting with for example chirarity oxazolidinon and optical active aldehyde to produce 2-substituted ACHPA analogs, then converting to amide derivative and protected amino derivative, obtaining a cyclic precursor, cyclizing them, removing the protect group, and coupling with carbonic acid or the like.
AN II UEEBAA
RARUFU EE RIBUERO
RIFU YANGU
