Title:
サイクリン依存性キナーゼ阻害剤及びその用法
Document Type and Number:
Japanese Patent JP2012526850
Kind Code:
A
Abstract:
The presently disclosed subject matter relates to methods and compositions for protecting healthy cells from damage due to DNA damaging agents. In particular, the presently disclosed subject matter relates to the protective action of selective cyclin dependent kinase 4/6 (CDK4/6) inhibitors administered to subjects that have been exposed to or that are at risk of exposure to DNA damage.
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Inventors:
Norman E Sharpless
Patrick Jay Roberts
Kwo-Kin Wong
Yang Liu
Solen Johnson
Patrick Jay Roberts
Kwo-Kin Wong
Yang Liu
Solen Johnson
Application Number:
JP2012511031A
Publication Date:
November 01, 2012
Filing Date:
May 13, 2010
Export Citation:
Assignee:
THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL
International Classes:
A61K45/00; A61K38/00; A61K38/22; A61K38/27; A61K47/34; A61K47/48; A61P1/04; A61P1/16; A61P3/10; A61P5/14; A61P7/00; A61P7/06; A61P9/00; A61P11/00; A61P11/06; A61P13/12; A61P15/00; A61P17/00; A61P17/06; A61P19/00; A61P19/02; A61P21/00; A61P21/04; A61P25/00; A61P27/02; A61P35/00; A61P37/00; A61P37/08; A61P43/00
Domestic Patent References:
| JP2001517652A | 2001-10-09 | |||
| JP2001526689A | 2001-12-18 |
Foreign References:
| WO2008050836A1 | 2008-05-02 | |||
| WO2008124406A2 | 2008-10-16 |
Other References:
JPN6014022848; Ｘ．Ｃｈｅｎ ｅｔ ａｌ．: Ｊｏｕｒｎａｌ ｏｆ Ｎａｔｉｏｎａｌ Ｃａｎｃｅｒ Ｉｎｓｔｉｔｕｔｅ ｖｏｌ．９２， Ｎｏ．２４, 2000, ｐ．１９９９-２００８
JPN6014022852; Ｐ．Ｌ．Ｔｏｏｇｏｏｄ ｅｔ ａｌ．: Ｊ． Ｍｅｄ． Ｃｈｅｍ ｖｏｌ．４８, 2005, ｐ．２３８８-２４０６
JPN6014022852; Ｐ．Ｌ．Ｔｏｏｇｏｏｄ ｅｔ ａｌ．: Ｊ． Ｍｅｄ． Ｃｈｅｍ ｖｏｌ．４８, 2005, ｐ．２３８８-２４０６
Attorney, Agent or Firm:
Akira Shimoda
Kenichiro Akao
Kenichiro Akao