Title:
シクロアストラゲノールモノグルコシド、その製造方法及び医薬用組成物としての使用
Document Type and Number:
Japanese Patent JP5294509
Kind Code:
B2
Abstract:
This invention provides a method for preparing cycloastragenol monoglucoside CMG (cydoastragenol-6-O-²-D-glucoside), comprising the steps of: a. using astragaloside IV or Astragali extracts prepared by a conventional method as raw materials and adding an appropriate solvent thereinto to form a raw material solution; b. adding hydrolase and allowing for hydrolysis at a constant temperature to obtain a hydrolysate; c. separating the hydrolysate with macroporous adsorption resin; and d. obtaining the product by purification and separation. The present invention further provides cycloastragenol-6-O-²-D-glucoside prepared according to the method of this invention as well as its use in the preparation of a medicament for treating cardiovascular diseases and pharmaceutical compositions comprising the same.
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Inventors:
Han In Mei
Shah Gunpin
Sue Wailen
Chao Changyou
Liu Yulin
Chao Nasia
Ryu Pen
Chang Si Sun
Fu Xiaoli
One lily
One waitin
Tan Lida
Shah Gunpin
Sue Wailen
Chao Changyou
Liu Yulin
Chao Nasia
Ryu Pen
Chang Si Sun
Fu Xiaoli
One lily
One waitin
Tan Lida
Application Number:
JP2010524334A
Publication Date:
September 18, 2013
Filing Date:
September 08, 2008
Export Citation:
Assignee:
TIANJIN INSTITUTE OF PHARMACEUTICAL RESEARCH
International Classes:
C12P33/00; A61K9/08; A61K9/19; A61K31/704; A61K36/00; A61K36/48; A61K47/02; A61K47/10; A61K47/26; A61K47/34; A61K47/36; A61K47/40; A61K47/42; A61P9/00
Domestic Patent References:
| JP2007524627A |
Foreign References:
| US20060292251 | ||||
| CN1544458A |
Other References:
Chem.Pharm.Bull.,Vol.31,No.2(1983)p.698-708
ABDALLAH, R. M.,Astragalosides from Egyptian Astragalus spinosus Vahl.,Pharmazie,1993年,48(6),p. 452-454
Chemistry of Natural Compounds,Vol.34,No.6(1998)p.672-675
Planta Medica,Vol.72,No.1(2006)p.4-8
ABDALLAH, R. M.,Astragalosides from Egyptian Astragalus spinosus Vahl.,Pharmazie,1993年,48(6),p. 452-454
Chemistry of Natural Compounds,Vol.34,No.6(1998)p.672-675
Planta Medica,Vol.72,No.1(2006)p.4-8
Attorney, Agent or Firm:
Masaki Hirota
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