Title:
CYCLODEXTRIN CLATHRATE OF CARBACYCLIN DERIVATIVE
Document Type and Number:
Japanese Patent JP2634787
Kind Code:
B2
Abstract:
PURPOSE: To obtain the subject novel compound exhibiting antihypertensive, bronchodilatative and antithrombotic functions or the like, and useful for, e.g. prevention or treatment of coronary heart disease, or inhibition of bronchial stricture.
CONSTITUTION: This clathrate is (5E)-(16RS)-16-methyl-18,18,19,19-tetradihydro-6a- carbaprostaglandin-12-β-cyclodextrin-clathrate shown by the formula. It is obtained by adding an aqueous solution of β-cyclodextrin dropwise to (5E)-(16 RS)-16-methyl-18,18,19,19-tetradihydro-6a-carbaprostaglandin-12 dissolved in ethanol and heated at 60°C, stirring the mixture at 60°C for 4 h, 45°C for 1 h and 25°C for 16 h, filtering the resultant precipitates under a vacuum, and washing and drying the precipitates. The clathrate is preferably in the stoichiometric ratio of carbacyclin/β-cyclodextrin of 1:2 (3). The dosage is preferably 1 to 1,500 μg/kg/day.
Inventors:
SUKUBARA BUERUNAA
FUOABURYUTSUGEN HERUMUUTO
DAARU HERUMUUTO
SHUTEYURUTSUEBEHYAA KURAUSUUSHUTEFUEN
TEIIRAUFU KAARUUHAINTSU
FUOABURYUTSUGEN HERUMUUTO
DAARU HERUMUUTO
SHUTEYURUTSUEBEHYAA KURAUSUUSHUTEFUEN
TEIIRAUFU KAARUUHAINTSU
Application Number:
JP9897595A
Publication Date:
July 30, 1997
Filing Date:
April 24, 1995
Export Citation:
Assignee:
SHEERINGU AG
International Classes:
A61K31/557; A61K47/48; A61P7/02; C07C59/46; A61P9/12; A61P11/08; A61P43/00; C07C51/00; C07C51/347; C07C59/125; C07C59/62; C07C67/00; C07C69/732; C07C405/00; C07D521/00; C08B37/00; C08B37/16; (IPC1-7): C07C59/46; C08B37/16
Attorney, Agent or Firm:
Toshio Yano (3 outside)