To a new cyclohexane derivative having an inhibitory action on selection, effective for treating, improving and preventing diseases such as inflammations, ischemic reperfusion disorder, autoimmune disease, tumor metastasis, etc.

This compound is shown by formula I (R1 is H, OH or the like; R2 is H or a 1-4C alkyl; R3 is H, a 1-4C alkyl or the like; X is a single bond or a 1-4C alkylene; R4 is CO2H or the like) such as N-(2-(1-((1R,3R,4R,5R)-1- methoxy-3,4,5-trihydroxycyclohexyl)methoxy)acetyl)-L-glutamic acid. The compound of the formula I is obtained, for example, by coupling a compound of formula II (P is a hydroxyl group-protecting group; R5 is H, a protected hydroxyl group or the like; Y is a hydroxyl group or the like) with a compound of formula III to give a compound of formula IV and properly protecting the whole protecting groups on the compound.