To obtain the subject compounds useful as an antibacterial agent, especially effective against mycoplasmas.
The compounds are represented by formula I [A is represented by formula II (R2 is H, a 2-8C cycloalkyl, etc.; D is O, S or NR5; R5 is H, a 2-8C cycloalkyl, etc.; at least one of E, G, L and M is N and the other are CR4; R4 is H, a halogen, etc.; T is O or S), etc.; R1 is azide, hydroxyl, OR8, etc.; R8 is a 1-8C acryl or a hydroxyl-protecting group[. The compounds represented by formula I are obtained by cyclizing a compound represented by formula III in the presence of an assistant (e.g. carbonyldiimidazole) and/or an acid (e.g. hydrochloric acid) in a solvent (e.g. methylene chloride) at -20 to +100°C. The compounds represented by formula I are capable of manifesting wide antimicrobial activities against Gram-positive bacteria, influenzal bacteria, anaerobix microorganisms and rapidly growing mycobacteria.
DEIITAA HEBIHI
BERUNTO RIITORU
MARUTEIN RUTSUPERUTO
SHIYUTEFUAN BARUTERU
WARUTERU GUARUNIIRI
HANNO BIRUTO
RAINAA ENDERUMAN
HAINNPEETAA KURORU
