Title:
ＬＳＤ１／ＨＤＡＣ二重阻害剤としてのシクロプロピル－アミド化合物
Document Type and Number:
Japanese Patent JP7034941
Kind Code:
B2
Abstract:
The present disclosure describes novel compounds of the general Formula (I), their analogs, tautomeric forms, stereoisomers, polymorphs, hydrates, solvates, pharmaceutically acceptable salts, pharmaceutical compositions, metabolites, and prodrugs thereof. These compounds can inhibit both LSD and HDAC and are useful as therapeutic or ameliorating agent for diseases that are involved in cellular growth such as malignant tumors, schizophrenia, Alzheimer's disease, parkinson's disease and the like.
Inventors:
Sri Dallan Rajagopal
Mahanandisha S. Haruru
Purshottam Dewang
Canaan Mulgan
Durga Prasana Kumar See H
Prabin Ayer
Chandrika Murakara
Danarakshmi Shivanandan
Threekara Nile
Mohad Zainuddin
Subra Mania Janardin Tantry
Chandler Gagendran
Sri Ram Rajagopal
Mahanandisha S. Haruru
Purshottam Dewang
Canaan Mulgan
Durga Prasana Kumar See H
Prabin Ayer
Chandrika Murakara
Danarakshmi Shivanandan
Threekara Nile
Mohad Zainuddin
Subra Mania Janardin Tantry
Chandler Gagendran
Sri Ram Rajagopal
Application Number:
JP2018557112A
Publication Date:
March 14, 2022
Filing Date:
May 08, 2017
Export Citation:
Assignee:
JUBILANT EPICORE LLC
International Classes:
C07C259/06; A61K31/165; A61K31/166; A61K31/167; A61K31/397; A61K31/4035; A61K31/415; A61K31/4155; A61K31/4174; A61K31/4192; A61K31/42; A61K31/422; A61K31/4365; A61K31/445; A61K31/45; A61K31/451; A61K31/454; A61K31/4545; A61K31/472; A61K31/495; A61K31/4985; A61K31/505; A61K31/506; A61K31/5377; A61K45/00; A61P35/00; A61P43/00; C07C237/20; C07C237/40; C07C259/08; C07C259/10; C07D205/04; C07D205/12; C07D209/44; C07D211/26; C07D211/76; C07D211/96; C07D217/04; C07D217/06; C07D231/12; C07D233/64; C07D239/26; C07D249/04; C07D261/08; C07D295/185; C07D401/04; C07D401/06; C07D401/12; C07D401/14; C07D403/12; C07D413/06; C07D413/12; C07D413/14; C07D417/06; C07D417/12; C07D487/04; C07D495/04
Domestic Patent References:
| JP4503074A | ||||
| JP10504821A | ||||
| JP2008509075A | ||||
| JP2019515878A | ||||
| JP2019504059A |
Foreign References:
| WO2010043721A1 | ||||
| WO2015123465A1 | ||||
| WO2017157322A1 | ||||
| WO2017116558A1 | ||||
| WO2016031815A1 | ||||
| WO2014084298A1 |
Other References:
REGISTRY(STN)[online],2006.03.08~2016.03.06, [検索日2021.02.09] , CAS登録番号 1880340-90-8,1879286-53-9,1869849-10-4, 1823059-14-8, 1624630-71-2,1424537-01-8,1375242-92-4, 1305331-60-5, 1304215-09-5, 1228143-74-5, 876273-57-3
Attorney, Agent or Firm:
Yamato Kento
Sei Morimoto
Nobuhiko Akiyama
Sei Morimoto
Nobuhiko Akiyama