Title:
β−セクレターゼ阻害剤としてのシクロプロピル縮合チアジン−２−アミン化合物及び使用方法
Document Type and Number:
Japanese Patent JP6576433
Kind Code:
B2
Abstract:
wherein variables A4, A5, A6, A8, and each of Ra, Rb, R1, R2, R3 and R7 of Formula I, independently, are defined herein. The invention also provides pharmaceutical compositions comprising the compounds, and uses of the compounds and compositions for treatment of disorders and/or conditions related to A-beta plaque formation and deposition, resulting from the biological activity of BACE. Such BACE mediated disorders include, for example, Alzheimer's Disease, cognitive deficits, cognitive impairments, schizophrenia and other central nervous system conditions. The invention further provides compounds of Formulas II and III, and sub-formula embodiments thereof, intermediates and methods for preparing compounds of the invention.
Inventors:
Allen, Jennifer Earl
Albert, Amega
Bourbo, Matthew Pee
Brown, James A
Chen, Jien Jay
Chuyoung, Yuen
Frohn, Michael Jay
Guzman-Perez, Angel
Harrington, Paul Lee
Riu, Lombin
Liu, Ching Yen
Row, Jonathan Dee
Boo Bang
Manning, James Earl
Minacci, Anna Elena
Nguyen, Thomas Tea
Nobuko Nishimura
Norman, Mark H
Petas, Ripping H
Pickrel, alexander jay
Chiang, Wen Yuen
Rumfeld, Shannon
Ruzasa, Robert M
Sigmund, Aaron See
Steck, Markian M
White, ryan dee
Shwe, Chiufen
Albert, Amega
Bourbo, Matthew Pee
Brown, James A
Chen, Jien Jay
Chuyoung, Yuen
Frohn, Michael Jay
Guzman-Perez, Angel
Harrington, Paul Lee
Riu, Lombin
Liu, Ching Yen
Row, Jonathan Dee
Boo Bang
Manning, James Earl
Minacci, Anna Elena
Nguyen, Thomas Tea
Nobuko Nishimura
Norman, Mark H
Petas, Ripping H
Pickrel, alexander jay
Chiang, Wen Yuen
Rumfeld, Shannon
Ruzasa, Robert M
Sigmund, Aaron See
Steck, Markian M
White, ryan dee
Shwe, Chiufen
Application Number:
JP2017506879A
Publication Date:
September 18, 2019
Filing Date:
August 05, 2015
Export Citation:
Assignee:
Amjien Incorporated
International Classes:
C07D417/12; A61K31/5415; A61K31/542; A61P7/04; A61P9/00; A61P25/00; A61P25/28; A61P43/00; C07D417/14; C07D471/04; C07D513/04
Domestic Patent References:
| JP2016510758A |
Foreign References:
| WO2014065434A1 | ||||
| WO2014059185A1 | ||||
| WO2013004676A1 | ||||
| WO2012147762A1 | ||||
| WO2011070781A1 | ||||
| WO2008133274A1 | ||||
| WO2007049532A1 |
Other References:
WOLTERING, Thomas J. et al.,BACE1 inhibitors: A head group scan on a series of amides,Bioorganic & Medicinal Chemistry Letters,2013年,Vol.23, No.14,pp.4239-4243,DOI: 10.1016/j.bmcl.2013.05.003
Attorney, Agent or Firm:
Kawaguchi International Patent Office