CYTOTOXIC AGENT INCLUDING POLYETHYLENE GLYCOL-CONTAINING TAXANE, AND THERAPEUTIC APPLICATION THEREOF

Title:

CYTOTOXIC AGENT INCLUDING POLYETHYLENE GLYCOL-CONTAINING TAXANE, AND THERAPEUTIC APPLICATION THEREOF

Document Type and Number:

Japanese Patent JP2011042679

Kind Code:

A

Abstract:

To provide a cytotoxic agent including one or more polyethylene glycol-containing taxanes linked to a cell binding agent.

A therapeutic composition for killing selected cell populations includes (A) a cytotoxic amount of one or more polyethylene glycol-containing taxanes covalently bonded to a cell binding agent through a linking group, and (B) a pharmaceutically acceptable carrier, diluent or excipient. A method for killing selected cell populations includes bringing target cells or tissue containing target cells into contact with an effective amount of the cytotoxic agent containing one or more polyethylene glycol-containing taxanes linked to a cell binding agent.

More Like This:

WO/2013/022960	CABAZITAXEL PORMULATIONS AND METHODS OF PREPARING THEREOF
JP4997318	Treatment of Atherosclerosis or Restenosis with Microtubule Stabilizers
JP2004528309	Molecular complex for cancer treatment

Inventors:

CHARI RAVI V J
MILLER MICHAEL LOUIS

Application Number:

JP2010238562A

Publication Date:

March 03, 2011

Filing Date:

October 25, 2010

Export Citation:

Click for automatic bibliography generation Help

Assignee:

IMMUNOGEN INC

International Classes:

C07D305/14; A61K31/337; A61K39/395; A61K45/00; A61K47/34; A61K47/48; A61P35/00; A61P43/00; C08G65/333

Attorney, Agent or Firm:

Shinjiro Ono
Kazuo Shamoto
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Hirose Shinobu

Previous Patent: IMPROVED VACCINE

Next Patent: HYDROALCOHOLIC COMPOSITION THICKENED USING POLYMER