Title:
D-PROLINE DERIVATIVE
Document Type and Number:
Japanese Patent JP3048558
Kind Code:
B2
Abstract:
PROBLEM TO BE SOLVED: To provide a new compound especially useful as pharmaceuticals for the treatment or prevention of amyloidosis.
SOLUTION: This compound is expressed by formula II or formula II [R is SH, benzyl or phenyl; R1 is H or a halogen; X is (CH2)n or the like; Y is S-S, (CH2)n of the like; X' is (CH2)n or the like; R2 is a lower alkyl, a lower alkoxy or the like; (n) is 0-3], preferably (R)-1-[(S)-3-[(S)-3-[(R)-2-carboxy- pyrrolidin-1-yl]-2-methyl-3-oxopropyl-disulfanyl]-2-methyl-propionyl]-pyrrolidine-2- carboxylic acid, etc. The objective compound can be produced e.g. by converting a compound of formula III successively to a compound of formula IV and then a compound of formula V by reacting in a solvent such as methanol in the presence of ammonia at room temperature in an inert atmosphere for about 2 hr.
Inventors:
Cornelia Hertel
Toasten Hoffman
Roland Jacob-Lawton
Roger David Norcross
Toasten Hoffman
Roland Jacob-Lawton
Roger David Norcross
Application Number:
JP30771998A
Publication Date:
June 05, 2000
Filing Date:
October 29, 1998
Export Citation:
Assignee:
F. Hoffman-La Rochille Age
International Classes:
A61K31/00; A61K31/40; A61K31/401; A61K31/4015; A61K38/08; A61P3/00; A61P3/10; C07K5/078; A61P9/04; A61P9/10; A61P25/00; A61P25/28; A61P43/00; C07D207/16; C07D207/22; C07D207/277; C07D401/14; C07D403/06; C07D403/12; C07D403/14; C07D405/14; C07D409/14; C07D413/14; C07D417/14; C07D419/14; C07D521/00; A61K31/00; (IPC1-7): C07D207/16; A61K31/401; A61P3/10; A61P9/04; A61P25/28; A61P43/00; C07D207/277
Domestic Patent References:
| JP58189158A | ||||
| JP661099A | ||||
| JP9157251A | ||||
| JP2157262A | ||||
| JP1230578A | ||||
| JP4961136A | ||||
| JP5419969A |
Other References:
【文献】米国特許4999417(US,A)
Attorney, Agent or Firm:
Hajime Tsukuni (3 outside)