DD HOMOSUTEROIDONOSEIZOHOHO - HOFFMANN LA ROCHE

Title:

DD HOMOSUTEROIDONOSEIZOHOHO

Document Type and Number:

Japanese Patent JPS5165750

Kind Code:

A

Abstract:

D-Homosteroids of the formula in which R<3> is (H,H) or ( alpha -H, beta -O-acyl), R<13> is lower alkyl, R<17a beta > is H or acyl, R<17a alpha > is ethynyl, 1-propynyl, vinyl, chloroethynyl, butadienyl or propadienyl, and the dotted line in the A ring indicates an additional C-C bond in the 4,5 or 5(10) position. These D-homosteroids have hormonal activity and can be prepared in a manner known per se starting from the 17-keto-D-homosteroids corresponding to the D-homosteroids of the formula I, on the one hand by reaction of these 17-ketosteroids with an organometallic compound supplying a radical R<17a alpha > or, on the other hand, by following this reaction by acylation of the resulting 17a beta -hydroxy-D-homosteroid.

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Inventors:

ANDORU FUYURUSUTO
MARUSERU MYUURAA
YURUKU ARUBERUTO BARUTAA GUUTS
URURITSUHI KURUBU
RUDORUFU HIIHYAATO

Application Number:

JP12387175A

Publication Date:

June 07, 1976

Filing Date:

October 16, 1975

Export Citation:

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Assignee:

HOFFMANN LA ROCHE

International Classes:

A61K31/21; A61K31/56; A61K31/12; C07J63/00; (IPC1-7): A61K31/12; C07J63/00

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