DEACETYLASE INHIBITORS AND USES THEREOF

Title:

DEACETYLASE INHIBITORS AND USES THEREOF

Document Type and Number:

Japanese Patent JP2014101380

Kind Code:

A

Abstract:

To provide deacetylase inhibitors and uses thereof.

The present invention provides novel compounds of formula (I) and pharmaceutical compositions thereof. The inventive compounds are useful as deacetylase inhibitors (e.g., histone deacetylase inhibitors) and may be useful in the treatment of proliferative diseases such as cancer. In particular, the inventive compounds are HDAC6 inhibitors. The invention also provides synthetic methods for preparing the inventive compounds. In the other embodiments, the present invention provides a pharmaceutical composition that includes a compound of the formula (I) of a cure effective dose, and a pharmaceutically acceptable excipient. In a specific embodiment, the pharmaceutical composition is useful in the treatment of proliferative diseases such as cancer.

More Like This:

WO/1990/009092	NOVEL POTENT INDUCERS OF TERMINAL DIFFERENTIATION AND METHOD OF USE THEREOF
JPH021442	2-(2-HYDROXY-3-PHENOXYPROPYLAMINO)ETHYLPHENOXY-ACETOAMIDE COMPOUND, ITS PREPARATION, THERAPEUTIC AGENT CONTAINING THIS COMPOUND FOR OBESITY AND RELATED SYMPTON AND INTERMEDIATE
WO/2023/170715	DUAL LSD1/HDAC INHIBITORS

Inventors:

TANG WEIPING
JAMES ELLIOT BRADNER
STUART L SCHREIBER

Application Number:

JP2014043515A

Publication Date:

June 05, 2014

Filing Date:

March 06, 2014

Export Citation:

Click for automatic bibliography generation Help

Assignee:

HARVARD COLLEGE
DANA FARBER CANCER INST INC

International Classes:

C07C259/06; A61K31/16; A61P29/00; A61P35/00; A61P43/00

Attorney, Agent or Firm:

Hidesaku Yamamoto
Natsuki Morishita

Previous Patent: VACCINATION BY TOPICAL APPLICATION OF GENETIC VECTOR

Next Patent: EXTRACT AND PREPARATION