象牙質コラーゲン線維の脱灰材料及びその製造方法と応用

Japanese Patent JP6928686

B2

The invention relates to a dentin collagen fibril demineralizing material, and a preparation method and application thereof. Specifically, the present invention relates to a conjugate of water-soluble chitosan and an aminocarboxylic acid metal chelating agent, which is used for dental demineralization, preferably dentin demineralization. The invention also discloses a dentin collagen fibril demineralizing material and a preparation method and application thereof, wherein the material of the invention is prepared from 0.5-1 part by mass of water-soluble chitosan, 10-30 parts by mass of EDTA, and 0.8-1.5 parts by mass of cross-linking agent. The invention also relates to a dental demineralization composition comprising a conjugate and a material of the invention. The conjugate, material and composition of the present invention can be used for dentin demineralization treatment before dental bonding and restoration. When used as a dentin collagen demineralizing agent, they have excellent selective extrafibrillar demineralization performance, good biological compatibility, effective anti-bacterial activity, endogenous matrix protease-inhibiting activity and extremely low cytotoxicity.

Niu, Lina
Chen, Zihua
Jen, Jimin
Guo, Jinmei
Yu, fan
Jao, Kai

JP2020043241A

September 01, 2021

March 12, 2020

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Air Force Medical University 4th Army Medical University

A61K6/30; A61K6/15; A61K6/898

JP2013525351A
JP7188424A
JP7112128A

Acta Biomaterialia,2019年,90,424-440

Yasunori Otsuka
Yasuhiro Otsuka
Shiro Takayanagi
Shuji Kimura
Osamu Shimoyama
Nagakawa Yukimitsu
Satoshi Kinoshita

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