防御組換えHAEMOPHILUS INFLUENZAE(インフルエンザ菌)高分子量タンパク質を発現させるためのプラスミドベクター

Japanese Patent JP4151844

B2

Protective high molecular weight (HMW) proteins are produced recombinantly by expression from E. coli by using a promoter effective in E. coli and a nucleic acid molecule which contains a modified operon of a non-typeable strain of Haemophilus. The modified operon contains the portion only of the A region which encodes the mature HMW protein and the complete B and C regions of the operon. Enhanced levels of expression of the HMW proteins can be achieved by including the E. coli cer gene, a further copy of the portion of the A region of the operon encoding the mature protein or both, in the expression vector. Nucleotide and deduced amino acid sequences of the hmw1 and hmw2 genes and HMW1 and HMW2 proteins, respectively, of several non-typeable Haemophilus influenzae strain have been identified.

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Loosemore, Sina, M.
Young, Yang-Ping
Crane, Michael, H.

JP2004037346A

September 17, 2008

February 13, 2004

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SANOFI PASTEUR LIMITED

C12N15/09; A61K9/127; A61K9/14; A61K9/48; A61K39/102; A61P31/04; C07K14/195; C07K14/285; C12N1/12; C12N1/13; C12N1/21; C12N15/31; C12N15/70; C12P21/02; A61K39/00; C12R1/93

WO1994021290A1

Infection and Immunity,1994年,Vol.62, No.8,p.3320-3328
Molecular Microbiology,1993年,Vol.9, No.5,p.1089-1095
Molecular Microbiology,1998年,Vol.27, No.3,p.617-630
Proc.Natl.Acad.Sci.USA,1993年,Vol.90,p.2875-2879
Bio/Technology,1986年,Vol.4,p.1006-1010
Infection and Immunity,1996年,Vol.64, No.4,p.1246-1251

Akio Miyazaki
Katsuhiro Ito
Ishibashi Masayuki

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