Title:
分解可能で生体適合性があるブロックコポリマー
Document Type and Number:
Japanese Patent JP4680900
Kind Code:
B2
Abstract:
New biocompatible block copolymers (I) contain at least two different block components, obtained by polycondensing a first diol (II) with a second diol (II), an alpha ,omega -dihydroxy-polyester (III) or an alpha ,omega -dihydroxy-polyether (IV) in presence of diisocyanate, diacid halide or phosgene, where (II) are obtained by transesterification of alpha ,omega -dihydroxy-(oligo-(3-(R)-hydroxybutyrate)-ethylene-oligo-3-(R)-hydroxybutyrate) with diglycolide or eta -caprolactone. (II) are also new. New biocompatible block copolymers (I) contain at least two chemically different block components, obtained by linear polycondensation of a first diol (II) with a second (same or different) diol (II), an alpha ,omega -dihydroxy-polyester (III) or an alpha ,omega -dihydroxy-polyether (IV) in presence of diisocyanate, diacid halide or phosgene. (II) are obtained by transesterification of alpha ,omega -dihydroxy-(oligo-(3-(R)-hydroxybutyrate)-ethylene-oligo-3-(R)-hydroxybutyrate) with diglycolide or eta -caprolactone. (III) are obtained by transesterification of poly-(R)-hydroxyvaleric acids (or their copolymers with 3-hydroxyvaleric acid) with ethylene glycol. (IV) are selected from alpha ,omega -dihydroxy-poly-(oxytetramethylenes), alpha ,omega -dihydroxy-poly-(oxytetraethylenes) and their copolymers with ethylene glycol or propylene glycol. Independent claims are included for: (a) the biocompatible diol intermediates (II) as new compounds; and (b) the preparation of (II), as described above.
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Inventors:
Neuen Schwander, Peter
Application Number:
JP2006519813A
Publication Date:
May 11, 2011
Filing Date:
July 06, 2004
Export Citation:
Assignee:
Aidgenesische Techniche Hochschule Zurich
International Classes:
C08G18/42; A61L17/10; A61L17/12; A61L27/00; A61L27/18; A61L31/00; A61L31/06; C08G18/73; C08G63/06; C08G63/16; C08G63/664; C08G63/91; C08G64/18
Domestic Patent References:
| JP8059811A | ||||
| JP10046013A | ||||
| JP5295075A | ||||
| JP10237166A |
Other References:
A. Lendlein, P. Neuenschwander, U.W. Suter,Tissue-compatible multiblock copolymers for medical applications, controllable in degradation rate and mechanical properties.,Macromolecular Chemistry and Physics,NL,1999年 1月11日,Vol.199, No.12,pp.2785-2796
A. Lendlein, M. Colussi, P. Neuenschwander, U.W. Suter,Hydrolytic degradation of phase-segregated multiblock copoly(ester urethane)s containing weak links.,Macromolecular Chemistry and Physics,NL,2001年10月10日,Vol.202, No.13,pp.2702-2711
A. Lendlein, M. Colussi, P. Neuenschwander, U.W. Suter,Hydrolytic degradation of phase-segregated multiblock copoly(ester urethane)s containing weak links.,Macromolecular Chemistry and Physics,NL,2001年10月10日,Vol.202, No.13,pp.2702-2711
Attorney, Agent or Firm:
Atsushi Aoki
Takashi Ishida
Tetsuji Koga
Hiroyuki Onoda
Masaya Nishiyama
Takashi Ishida
Tetsuji Koga
Hiroyuki Onoda
Masaya Nishiyama