Title:
DEHALOGENATION OF HALOGEN-SUBSTITUTED ARYLALKYLAMINE
Document Type and Number:
Japanese Patent JP3930922
Kind Code:
B2
Abstract:
PROBLEM TO BE SOLVED: To dehalogenate an arylalkylamine enantiomer while keeping the optical activity on the C atom having amino group.
SOLUTION: An enantiomer having one optical center on the C atom labeled with * and expressed by formula I ((m) is 1, 2 or 3; (n) is 0-4; R1 and R2 are each H, a 1-10C alkyl, an aryl or together with *C form a 3-8 membered ring; R3 and R4 are each H, a 1-10C alkyl, an aryl or together with N form a 3-8 membered ring or together with R1 or R2 form a 3-8 membered ring; X is Cl, Br or I) is made to react with a hydrogenating agent (e.g. sodium formate) in the presence of a hydrogenation catalyst containing a transition metal (e.g. Raney nickel) to obtain an enantiomer of formula II retaining the optical center *. the dehalogenation is carried out at 0-250°C using 1-25wt.% of the catalyst based on the substrate to be dehalogenated.
Inventors:
Claus Ditrich
Application Number:
JP21483896A
Publication Date:
June 13, 2007
Filing Date:
August 14, 1996
Export Citation:
Assignee:
BASF Aktiengesellschaft
International Classes:
B01J25/02; B01J23/44; B01J31/28; C07C211/27; C07B35/06; C07B53/00; C07B61/00; C07C209/74; C07C211/28; (IPC1-7): C07C211/27; B01J23/44; B01J25/02; B01J31/28; C07B53/00; C07C209/74; //C07B61/00; C07M7:00
Domestic Patent References:
| JP60218330A |
Other References:
J.Org.Chem.,(1975),40(11),p.1562-7
Attorney, Agent or Firm:
Toshio Yano
Toshiomi Yamazaki
Reinhard Einsel
Toshiomi Yamazaki
Reinhard Einsel