Title:
DEMENTIA THERAPEUTIC AGENT SCREENING METHODS FOR MEMORY IMPROVEMENT
Document Type and Number:
Japanese Patent JP2023097901
Kind Code:
A
Abstract:
To provide a method for screening a medicine to treat dementia by improving memory.SOLUTION: The invention is based on the finding that Nedd4-2, which is one of E3 (ubiquitin ligase) that determines substrate specificity of ubiquitination, suppresses memory capacity. A postsynaptic transmembrane protein, Prr7, is identified as a substrate for Nedd4-2. As a result, it is found that a candidate therapeutic agent for dementia is obtained by screening a substance that inhibit ubiquitination of Prr7 by Nedd4-2 to complete the invention.SELECTED DRAWING: Figure 2
Inventors:
KAWABE HIROSHI
Application Number:
JP2021214275A
Publication Date:
July 10, 2023
Filing Date:
December 28, 2021
Export Citation:
Assignee:
UNIV GUNMA
International Classes:
A01K67/027; G01N33/68; G01N33/15; G01N33/50; G01N33/53; G01N33/543
Attorney, Agent or Firm:
Patent Attorney Corporation Shuwa Patent Office