デンドリマー－生体接着性ポリマーヒドロゲルナノ接着剤およびその使用

Japanese Patent JP7334994

B2

A nanoglue is formed with one or more bioadhesive polymers, one or more dendrimers, and optionally one or more therapeutic, prophylactic, or diagnostic agents. The bioadhesive polymers and dendrimers are modified with functional groups to permit crosslinking upon one or more stimuli, e.g., ultraviolet irradiation, and form hydrogel in situ at tissue sites. In the repair of corneal wounds, the nanoglue leads to improved rate of healing with less scarring and less inflammation, compared to non-treated cornea or ones treated with sutures. Therapeutic agents can be covalently conjugated to the precursor components and be delivered to specific eye compartments, providing a more efficacious treatment formulation of ocular disorders than delivering drugs in their free forms. Methods of making and using the hydrogel and hydrogel precursor compositions are also provided.

WO/2018/197946	HYDROGEL COMPOSITIONS INCLUDING FIBERS AND METHODS OF USE THEREOF
JP2002526396	[Title of the Invention] Compositions, articles, and methods of using biodegradable terephthalate polyester-polyphosphonate and polyester-polyphosphite.
WO/2024/047445	BIODEGRADABLE LUNG SEALANTS

Canaan Langara Manu Jam
Walter Stark
Shiva Pramos Kambalm Patty
uri soiberman
Samuel Yiu
Abdul-Ella Abad Al-Twaqi

JP2021137883A

August 29, 2023

August 26, 2021

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The Johns Hopkins University

A61L24/04; A61K9/06; A61K31/56; A61K31/573; A61K45/00; A61K47/10; A61K47/32; A61K47/36; A61K47/38; A61K47/56; A61K49/00; A61K49/04; A61K49/12; A61K51/06; A61L24/00; A61L24/06; A61L24/08; A61L24/10; A61L26/00; A61P17/02; A61P27/02; A61P27/14

JP2014516627A
JP2004523624A

Progress in Polymer Science,2014年,Vol.39,p.1973-1986

Shusaku Yamamoto

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