Title:
DENDRITIC CELL HYBRID
Document Type and Number:
Japanese Patent JP2008263997
Kind Code:
A
Abstract:
To provide a composition for stimulating an immune system in association with cell-mediated immunity.
The composition comprises a plurality of cells, wherein at least half thereof are fused cells, each of which is produced by fusion of at least one mammalian dendritic cell and at least one mammalian non-dendritic cell expressing a cell surface antigen, and at least half of the fused cells expressing such amounts of (a) MHC class II molecules, (b) B7 and (c) cell surface antigens as to be effective for stimulating an immune system, respectively. A method for producing such a dendritic cell hybrid is also provided.
Inventors:
GONG JIANLIN
KUFE DONALD
KUFE DONALD
Application Number:
JP2008147567A
Publication Date:
November 06, 2008
Filing Date:
June 05, 2008
Export Citation:
Assignee:
DANA FARBER CANCER INST INC
International Classes:
C12N5/10; C12N15/02; A61K35/12; A61K39/00; A61P1/16; A61P31/04; A61P31/12; A61P33/02; A61P35/00; A61P37/04; A61P37/06; C12N5/02; C12N5/16; A61K38/00
Foreign References:
| WO1996030030A1 | 1996-10-03 | |||
| WO1996030030A1 | 1996-10-03 |
Other References:
JPN6011009549; Ｐｒｏｃ．Ａｍｅｒｉｃａｎ Ａｓｓｏｃ．Ｃａｎｃｅｒ Ｒｅｓ．， ｖｏｌ．３８， ｐ．６１６， ＃４１３７ （Ｍａｒｃｈ １９９７）
JPN6013000789; Ｊ． Ｅｘｐ． Ｍｅｄ． Ｖｏｌ．１８０, 1994, ｐ．８３-９３
JPN6013000790; Ｐｒｏｃ． Ｎａｔｌ． Ａｃａｄ． Ｓｃｉ． ＵＳＡ Ｖｏｌ．９３, 1996, ｐ．２５８８-２５９２
JPN6013000791; 斉藤隆ほか編: 実験医学別冊 ＢｉｏＳｃｉｅｎｃｅ用語ライブラリー 免疫 , 1995, ｐ．９４〜９６, 株式会社羊土社
JPN6013000789; Ｊ． Ｅｘｐ． Ｍｅｄ． Ｖｏｌ．１８０, 1994, ｐ．８３-９３
JPN6013000790; Ｐｒｏｃ． Ｎａｔｌ． Ａｃａｄ． Ｓｃｉ． ＵＳＡ Ｖｏｌ．９３, 1996, ｐ．２５８８-２５９２
JPN6013000791; 斉藤隆ほか編: 実験医学別冊 ＢｉｏＳｃｉｅｎｃｅ用語ライブラリー 免疫 , 1995, ｐ．９４〜９６, 株式会社羊土社
Attorney, Agent or Firm:
Hatsushi Shimizu