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Patent Searching and Data


Title:
DEPOT
Document Type and Number:
Japanese Patent JPH0656840
Kind Code:
A
Abstract:

PURPOSE: To provide an insoluble compd. useful as a therapeutic drug for various psychoses and especially for depot.

CONSTITUTION: This compd. is a pamoate or hemipamoate salt of trans-5- chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenz (2,3:6,7)oxepino-(4,5-c)pyrrole. The compd. is obtd. by the reaction of tans-5-chloro-2-methyl-2,3,3a,12b- tetrahydro-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrole and pamo acid in a polar solvent. The depot is prepared by compounding the pamoate compd. above described with a vegetable oil. The chemical name of pamo acid is 4,4'-methylene bis[3-hydroxy-2-naphthalene carboxylic acid. The obtd. compd. has a suppressing activity for the central nervous system and excellent antihistaminic effect and antiserotonergic effect and is useful for the treatment of tension, excitement, anxiety, psychosis and schizophrenia.


Inventors:
PETORUSU YOHANNESU MARIA FUAN
Application Number:
JP10696993A
Publication Date:
March 01, 1994
Filing Date:
May 07, 1993
Export Citation:
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Assignee:
AKZO NV
International Classes:
A61K9/107; A61K31/395; A61K31/40; A61K47/38; A61P25/18; A61P25/20; C07D207/00; C07D491/044; A61K; C07C; C07D; (IPC1-7): C07D491/044; A61K9/107; A61K31/40; A61K47/38
Attorney, Agent or Firm:
Yoshio Kawaguchi (2 outside)