NEW MATERIAL:A derivative of hydrogenated macrolide antibiotic substance I (R1 is H, acetyl, propionyl, butylyl, isobutylyl, isovarelyl) or its salt.
EXAMPLE: Tetrahydroisoleucomycin A5.
USE: Antibiotic angent, Stable to acid, free of bitter aste, and having excellent phylactic and remedying effects.
PROCESS: The objective compound I is prepared by the catalytic reduction of an allyl rearranged antibiotic substance III in a solvent such as methanol, ethanol, etc., in the presence of a catalyst such as Pt catalyst, Pd catalyst, etc., thereby hydrogenating only the carbon atoms of conjugated double bonds at 9 and 11 position of a macro-ring lactone group of the compound III. The antibiotic sulbstance III is prepared by the allyl rearrangement of a compound II
| JPS5927899 | DE(MYCINOSYLOXY)TYLOSIN DERIVATIVE |
| WO/2004/000864 | 11-C-SUBSTITUTED KETOLIDES |
| JP2530344 | [Title of Invention] Reduced avermectin derivative |
SATOU YUTAKA
OOMURA SATOSHI
WATANABE TETSUO
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