DERIVATIVE OF SACCHARIDES AND ITS PRODUCTION

Title:

DERIVATIVE OF SACCHARIDES AND ITS PRODUCTION

Document Type and Number:

Japanese Patent JP2000014395

Kind Code:

A

Abstract:

To obtain a new saccharide derivative useful as a diagnostic marker for diabetes, a control index for blood sugar, etc., comprising a saccharide derivative prepared by converting a specific hydroxy group of a saccharide into another substituent group by an enzyme reaction in the presence of a mediator.

This new 3-position derivative of saccharides is shown by formula I (R1 is H, OH, a saccharide residue, a phosphate group, phenoxy, an ester, an ether or a carboxylic acid; R2 is =O, OH, NH2 or NHCOCH3; R3 is =NOH or NH2) or formula II (R4 is 7-nitrobenzfurazane group or a fluorescent labeled group) (e.g. 3-keto-1,5-anhydroglucitol or the like) and is useful as a diagnostic marker for diabetes and a control index for blood sugar and for elucidating physiological meaning of 1,5-anhydroglucitol, etc. The saccharide derivative is obtained by carrying out an enzyme reaction in the presence of a mediator so as to convert a specific hydroxy group of a saccharide into another substituent group.

Inventors:

HAYADE KOJI
TSUGAWA WAKAKO
HAMAFUJI TETSUO

Application Number:

JP18736898A

Publication Date:

January 18, 2000

Filing Date:

July 02, 1998

Export Citation:

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Assignee:

HAYADE KOJI
INT REAGENTS CORP

International Classes:

G01N21/78; C07D309/30; C07H5/04; C07H11/04; C07H13/00; C07H15/00; C12P17/06; C12P19/00; C12R1/645; (IPC1-7): C12P17/06; C12P19/00; G01N21/78

Domestic Patent References:

JPH06189755A	1994-07-12
JPH0767697A	1995-03-14

Other References:

ENZYME. MICROB. TECHNOL., vol. 22, no. 4, JPN6008028106, March 1998 (1998-03-01), pages 269 - 274, ISSN: 0001060204

Attorney, Agent or Firm:

Aoyama Ryo (1 person outside)

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