Title:
ジヒドロ又はテトラヒドロナフタレンの誘導体及びそれらを含む医薬組成物
Document Type and Number:
Japanese Patent JP4959041
Kind Code:
B2
Abstract:
Dihydro or tetrahydronaphthalene derivatives (I) are new. Dihydro or tetrahydronaphthalene derivatives of formula (I), their stereoisomers and salts are new. R1 = H, 1-6C alkyl or 1-6C acyl (both optionally substituted); R2, R3 = H or 1-6C alkyl (optionally substituted); R2 + R3 = 3-7C cycloalkyl; R4 = aryl or heteroaryl (both optionally substituted); X = O or CH2; Y = OH, 1-6C alkyloxy or NR5R6; R5, R6 = H or 1-6 C alkyl (optionally substituted); R5 + R6 = 3- to 15-membered heterocylic (optionally substituted) or polycyclic ring, optionally comprising an additional O, S or N; and Z = single or double bond. Independent claims are also included for: (1) the preparation of (I); and (2) the intermediates compounds of formulas (V), (VI) and (VII).
Inventors:
Francois nik
Application Number:
JP12584699A
Publication Date:
June 20, 2012
Filing Date:
May 06, 1999
Export Citation:
Assignee:
Aventis Pharma Societe Anonym
International Classes:
A61K31/16; A61K31/00; C07C59/54; A61K31/19; A61K31/215; A61P19/00; A61P19/10; C07C45/59; C07C45/63; C07C45/68; C07C47/575; C07C51/353; C07C51/367; C07C59/56; C07C59/72; C07C67/31; C07C67/347; C07C69/732; C07C69/734; C07C231/12; C07C235/34; C07D311/58
Domestic Patent References:
| JP10503215A |
Foreign References:
| WO1997032837A1 |
Other References:
Journal of Medicinal Chemistry,1994年,Vol.37,p.1550-1552
Attorney, Agent or Firm:
Axis International Patent Business Corporation
Motohiro Kurauchi
Motohiro Kurauchi