Title:
フルオレン、アントラセン、キサンテン、ジベンゾスベロン、及びアクリジンの誘導体、並びに、それらの使用
Document Type and Number:
Japanese Patent JP5782586
Kind Code:
B2
Abstract:
Chemical agents, such as disulfonamide derivatives of fluorene, anthracene, xanthene, dibenzosuberone and acridine, and similar heterocyclic ring structures, including salts thereof, that act as anti-cancer and anti-tumor agents, especially where such agents modulate the activity of the Wnt/β-catenin signaling pathway, and serve to reduce β-catenin levels present in cells, such as cancer cells, or where the agents modulate levels of gene expression in cellular systems, including cancer cells, are disclosed, along with methods for preparing such agents, as well as pharmaceutical compositions containing such agents as active ingredients and methods of using these as therapeutic agents.
Inventors:
Chorodee, Withlaw M.
Zhang, Yi
Zuck, Carina
Watty, Jeffrey, W. H.
Aura, zoe
Strobel, Jeffrey
Jol
Sheila Bread, Sheila
Padilla, Janak
Zhang, Yi
Zuck, Carina
Watty, Jeffrey, W. H.
Aura, zoe
Strobel, Jeffrey
Jol
Sheila Bread, Sheila
Padilla, Janak
Application Number:
JP2010507482A
Publication Date:
September 24, 2015
Filing Date:
May 09, 2008
Export Citation:
Assignee:
Dogwood Pharmaceuticals, Incorporated
International Classes:
C07D223/04; A61K31/135; A61K31/136; A61K31/16; A61K31/341; A61K31/395; A61K31/403; A61K31/437; A61K31/438; A61K31/4545; A61K31/4709; A61K31/4725; A61K31/4985; A61K31/5377; A61K31/55; A61K31/5513; A61K31/553; A61P35/04; C07C311/16; C07C311/18; C07C311/19; C07C311/20; C07C311/21; C07D209/02; C07D211/96; C07D215/58; C07D217/08; C07D221/20; C07D225/02; C07D243/08; C07D267/10; C07D273/01; C07D295/22; C07D307/52; C07D405/04; C07D471/04; C07D471/08; C07D487/08; C07D491/113
Domestic Patent References:
| JP57118540A | ||||
| JP55019277A |
Foreign References:
| US20040019042 | ||||
| WO2006113097A1 | ||||
| US3919211 |
Other References:
Blazquez, M. Teresa et al.,Acridone heterocycles as fluorescent sensors for anions,Heterocycles,2006年,69,73-81
Attorney, Agent or Firm:
Hiroyuki Niwa
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