Title:
【発明の名称】ビシクロポリアザ大環状ホスホン酸、結合体、造影剤及び製造
Document Type and Number:
Japanese Patent JPH07502043
Kind Code:
A
Abstract:
Bicyclopolyazamacrocyclophosphonic acid compounds are disclosed which may form inert complexes with Gd, Mn or Fe ions. The overall charge of the complex can be varied to alter the in vivo biolocalization. Such complexes can be covalently attached to an antibody, antibody fragment or other biologically active molecule to form conjugates. The complexes and conjugates are useful as contrast agents for diagnostic purposes. Processes for the preparation of the ligand, complex and conjugate are also disclosed.
Inventors:
Kiefer, Girly E.
Simon, James
Gurrich, Joseph Earl
Simon, James
Gurrich, Joseph Earl
Application Number:
JP51107293A
Publication Date:
March 02, 1995
Filing Date:
December 10, 1992
Export Citation:
Assignee:
THE DOW CHEMICAL COMPANY
International Classes:
A61K31/675; A61K49/00; A61K49/06; A61K51/04; C07D471/16; C07D487/08; C07F9/38; C07F9/40; C07F9/6524; C07F9/6561; (IPC1-7): C07F9/6524; A61K49/00; C07D471/16; C07D487/08; C07F9/6561
Attorney, Agent or Firm:
Takashi Ishida (3 others)