【発明の名称】キラル触媒、接触酸化及び不均化反応並びにエポキシクロマン及びタキソルの製造方法

Japanese Patent JP3497165

B2

Chiral catalysts for enantioselectively epoxidizing a prochiral olefin and for enantioselectively oxidizing a prochiral sulfide are disclosed, together with methods of using such catalysts. In accordance with one aspect of the invention, the catalyst is a salen derivative which has general structure (I). In accordance with another aspect of the present invention is a method of producing an epoxychroman using a chiral catalyst. In accordance with this method, a chromene derivative, an oxygen atom source, and a chiral catalyst are reacted under such conditions and for such time as is needed to epoxidize said chromene derivative. In accordance with yet another aspect of this invention is a method of enantioselectively epoxidizing a cis-cinnamate derivative to make taxol or an analog thereof. In accordance with another aspect a method of disproportionation of hydrogen peroxide using the catalysts of the present invention is disclosed.

Jacobson Eric N
Tsang Way
Denry

JP50467093A

February 16, 2004

August 26, 1992

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Research Corporation Technologies, Incorporated

B01J31/18; B01J31/22; C07C251/16; C07C315/02; C07D301/06; C07D301/08; C07D301/12; C07D301/14; C07D305/14; C07D493/04; C07D493/10; C07F7/28; C07F9/00; C07F11/00; C07F13/00; C07F15/00; C07F15/02; C07F15/04; C07F15/06; (IPC1-7): B01J31/22

JP5507645A

Ｅｒｉｃ Ｎ．Ｊａｃｏｂｓｅｎ，ｅｔ ａｌ．，Ｅｌｅｃｔｒｏｎｉｃ Ｔｕｎｉｎｇ ｏｆ Ａｓｙｍｍｅｔｒｉｃ Ｃａｔａｌｙｓｔｓ，Ｊ．Ａｍ．Ｃｈｅｍ．Ｓｏｃ．，１９９１年 ８月１４日，１１３，６７０３−６７０４
Ｗｅｉ Ｚｈａｎｇ，ｅｔ ａｌ．，Ｅｎａｎｔｉｏｓｅｌｅｃｔｉｖｅ Ｅｐｏｘｉｄａｔｉｏｎ ｏｆ Ｕｎｆｕｎｃｔｉｏｎａｌｉｚｅｄ Ｏｌｅｆｉｎｅｓ Ｃａｔａｌｙｚｅｄ ｂｙ（Ｓａｌｅｎ）ｍａｎｇａｎｅｓｅ Ｃｏｍｐｌｅｘｅｓ，Ｊ．Ａｍ．Ｃｈｅｍ．Ｓｏｃ．，１９９０年，１１２，２８０１−２８０３

Minoru Nakamura (5 others)

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