Title:
【発明の名称】骨欠損状態を処置するための組成物および方法
Document Type and Number:
Japanese Patent JP2001510450
Kind Code:
A
Abstract:
Compounds containing two aromatic systems covalently linked through a linker containing one or more atoms, or "linker" defined as including a covalent bond per se so as to space the aromatic systems at a distance 1.5-15 ANGSTROM , are effective in treating conditions associated with bone deficits. The compounds can be administered to vertebrate subjects alone or in combination with additional agents that promote bone growth or that inhibit bone resorption. They can be screened for activity prior to administration by assessing their ability to effect the transcription of a reporter gene coupled to a promoter associated with a bone morphogenetic protein and/or their ability to stimulate calvarial growth in model animal systems.
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Inventors:
Ohm, Mark W.
Bind tools, nando
Robins, Kirk Gee.
Harris, Scott M.
Maria Kontoianni
Harley, Lawrence H.
Carwin, Sheen M.
Mandy, Gregory Earl.
Petrie, charles
Bind tools, nando
Robins, Kirk Gee.
Harris, Scott M.
Maria Kontoianni
Harley, Lawrence H.
Carwin, Sheen M.
Mandy, Gregory Earl.
Petrie, charles
Application Number:
JP51952998A
Publication Date:
July 31, 2001
Filing Date:
October 23, 1997
Export Citation:
Assignee:
Zymogenetics, Inc.
Osteoscreen, Incorporated
BOARD OF REGENTS,THE UNIVERSITY OF TEXAS SYSTEM
Osteoscreen, Incorporated
BOARD OF REGENTS,THE UNIVERSITY OF TEXAS SYSTEM
International Classes:
C07D239/74; A61K31/00; A61K31/136; A61K31/192; A61K31/196; A61K31/215; A61K31/4184; A61K31/426; A61K31/428; A61K31/437; A61K31/44; A61K31/444; A61K31/47; A61K31/4709; A61K31/498; A61K31/502; A61K31/517; A61K31/53; A61K31/535; A61K31/5415; A61K31/549; A61K31/655; A61P19/08; A61P19/10; C07C49/84; C07C69/92; C07C225/32; C07C233/55; C07C233/59; C07C233/80; C07C235/38; C07C237/20; C07C243/22; C07C243/32; C07C243/34; C07C243/38; C07C245/08; C07C251/20; C07C251/28; C07C251/48; C07C251/66; C07C251/86; C07C259/10; C07C311/39; C07C323/62; C07C337/06; C07D213/53; C07D213/76; C07D213/78; C07D213/85; C07D215/12; C07D215/38; C07D235/08; C07D235/22; C07D241/42; C07D265/16; C07D277/20; C07D277/56; C07D277/64; C07D277/82; C07D279/16; C07D285/16; C07D401/06; C07D401/12; C07D403/04; C07D471/04; C07D521/00; (IPC1-7): A61K31/136; A61K31/00; A61K31/192; A61K31/215; A61K31/4184; A61K31/426; A61K31/428; A61K31/437; A61K31/44; A61K31/47; A61K31/4709; A61K31/502; A61K31/517; A61K31/53; A61K31/535; A61K31/5415; A61K31/549; A61P19/08; A61P19/10; C07C49/84; C07C69/92; C07C225/32; C07C233/55; C07C233/59; C07C233/80; C07C235/38; C07C237/20; C07C243/22; C07C243/32; C07C243/34; C07C243/38; C07C245/08; C07C251/20; C07C251/28; C07C251/48; C07C251/66; C07C251/86; C07C259/10; C07C311/39; C07C323/62; C07C337/06; C07D213/53; C07D213/76; C07D213/78; C07D213/85; C07D215/12; C07D215/38; C07D235/08; C07D235/22; C07D239/74; C07D241/42; C07D265/16; C07D277/56; C07D277/64; C07D277/82; C07D279/16; C07D285/16; C07D401/06; C07D401/12; C07D403/04; C07D471/04; C07D521/00
Attorney, Agent or Firm:
Shusaku Yamamoto