Title:
【発明の名称】マクロサイクリックラクトン、組成物、および使用方法
Document Type and Number:
Japanese Patent JP2001510838
Kind Code:
A
Abstract:
The present invention provides compound of the formula:wherein R1 and R2 are the same or different and are independently H, C1-C6 straight-chain or branched saturated or unsaturated alkyl, aryl, R6CH2-, R6CO-, or R6SO2-, wherein R6 is H, C1-C6 straight-chain or branched saturated or unsaturated alkyl, or aryl; R3 is H, C1->C6 straight-chain or branched-chain saturated alkyl, aryl, an oxime, or an oxime methyl ether; at least one aromatic ring position is optionally substituted with a substituent selected from the group consisting of halo, nitro, amino, hydroxyl, thio, acyl, C1-C6 alkyl, and cyano; and Z is a contiguous linker comprising a chain of 7-10 atoms (including heteroatoms) which atoms, together with the five atoms beginning with the carbon of the aromatic ring in meta-relationship with OR1 and ending with the carbon directly attached to the alkyl oxygen of the lactone, which carbons are covalently bonded to either end of linker Z, integrally form a 12-15 membered ring; or a pharmaceutically acceptable salt, an ester, or a prodrug thereof.The present invention further provides a pharmaceutical composition, and a method of preventing or treating cancer, using at least one compound of the present invention, optionally in conjunction with an additional compound other than a compound of the present invention.
Inventors:
Boyd, Michael Earl.
McKee, Tonya Si.
Cardelina The Second, John H.
Butler, John A.
Ericsson, Karen
Galinis, Deborah
Panel, lewis
McKee, Tonya Si.
Cardelina The Second, John H.
Butler, John A.
Ericsson, Karen
Galinis, Deborah
Panel, lewis
Application Number:
JP2000504132A
Publication Date:
August 07, 2001
Filing Date:
July 23, 1998
Export Citation:
Assignee:
US HEALTH (US)
International Classes:
A61K31/357; A61K31/365; A61P35/00; C07D313/00; C07D321/00; (IPC1-7): C07D313/00; A61K31/365; A61P35/00; C07D321/00
Attorney, Agent or Firm:
Takashima Hajime