Title:
【発明の名称】マロン酸ベースのマトリックスメタロプロテイナーゼインヒビター
Document Type and Number:
Japanese Patent JPH10511342
Kind Code:
A
Abstract:
There is described the use of a compound represented by general formulae (I), (II) or (III), for the inhibition of matrix metalloproteinases (MMP), wherein X1 is oxygen or sulfur, R1 is OH, SH, CH2OH, CH2SH or NHOH, R2 is a residue of 2 to 10 hydrocarbon backbone atoms, which binds to the amino acid 161 of HNC, said residue being saturated or unsaturated, linear or branched, and contains preferably homocyclic or heterocyclic structures, X2 is oxygen or sulfur and binds as hydrogen acceptor on amino acid 160 of HNC, Y is a residue which binds to the S1' pocket of HNC and consists of at least 4 backbone atoms Z1-Z2-Z3-Z4-R3, and R3 is n-propyl, isopropyl, isobutyl or a residue with at least 4 backbone atoms, which is not larger than a tricyclic ring system. These compounds bind to MMPs in a manner different from the mode of binding of the inhibitors of the state of the art.
Inventors:
Morrodale, Lewis
Bode, Wolfram
Glams, frank
Hiubel, Robert
Bode, Wolfram
Glams, frank
Hiubel, Robert
Application Number:
JP51733696A
Publication Date:
November 04, 1998
Filing Date:
December 08, 1995
Export Citation:
Assignee:
Boehringer Mannheim Gesellschaft Mitt Beschlenktel Haftung
International Classes:
A61K31/16; A61K31/165; A61K31/195; A61K31/34; A61K31/341; A61K31/495; A61K31/66; A61K38/00; C07D307/52; A61P1/02; A61P1/04; A61P19/10; A61P29/00; A61P43/00; C07C233/54; C07C259/06; C07F9/30; C07F9/38; C07K5/06; C07K5/08; C07K5/097; C12N9/64; (IPC1-7): C07C233/54; A61K31/165; A61K31/195; A61K31/34; A61K31/66; A61K38/00; C07D307/52; C07F9/38
Attorney, Agent or Firm:
Takashi Ishida (3 others)