Title:
【発明の名称】蒸気透過性コーチングを有する浸透デバイス
Document Type and Number:
Japanese Patent JP2853903
Kind Code:
B2
Abstract:
PCT No. PCT/IB94/00114 Sec. 371 Date Jan. 17, 1996 Sec. 102(e) Date Jan. 17, 1996 PCT Filed May 19, 1994 PCT Pub. No. WO95/03033 PCT Pub. Date Feb. 2, 1995An osmotic device that, following the imbibement of water vapor, provides for the controlled release of a beneficial agent to an aqueous environment. The device comprises a hydrophilic formulation including a beneficial agent, and if needed, an osmagent, surrounded by a wall. The wall is formed at least in part of a semipermeable hydrophobic membrane having an average pore size between about 0.1 mu m and 30 mu m. The pores are substantially filled with a gas phase. The hydrophobic membrane is permeable to water in the vapor phase and the hydrophobic membrane is impermeable to an aqueous medium at a pressure less than about 100 Pa. The beneficial agent is released, for example, by osmotic pumping or osmotic bursting upon imbibement of sufficient water vapor into the device core. These devices minimize incompatibilities between the beneficial agent and ions (such as hydrogen or hydroxyl) or other dissolved or suspended materials in the aqueous medium, since contact between the beneficial agent and the aqueous medium does not occur until after the beneficial agent is released. This results from the semipermeable membrane's selective permeability for water vapor. In addition, the high water fluxes attendant with these vapor-permeable membranes facilitate the delivery of beneficial agents having low solubilities, and the delivery of high dosages of beneficial agents.
Inventors:
KASURAA EDOWAADO ERU
HAABITSUGU SUKOTSUTO EMU
SUMISU KERII ERU
UAN EIKUREN HOORU
HAABITSUGU SUKOTSUTO EMU
SUMISU KERII ERU
UAN EIKUREN HOORU
Application Number:
JP50503595A
Publication Date:
February 03, 1999
Filing Date:
May 19, 1994
Export Citation:
Assignee:
FUAIZAA INC
International Classes:
A61K9/00; C07C201/08; A61K9/32; C07C201/12; C07C205/11; C07C205/19; C07C205/23; C07C205/26; C07C205/34; C07C205/42; C07C215/14; C07C271/08; C07C301/00; C07C309/67; C07C309/73; C07C319/14; C07C323/16; C07C323/25; C07C323/29; C08G18/38; C08G59/50; C08G63/685; C08L101/00; C09D163/00; G03F7/00; G03F7/004; G03F7/039; G03F7/16; (IPC1-7): A61K9/00
Domestic Patent References:
| JP61103821A | ||||
| JP7500264A |
Other References:
【文献】米国特許3832252(US,A)
Attorney, Agent or Firm:
Kazuo Shamoto (4 outside)