Title:
【発明の名称】抗腫瘍治療のためのサイトカインを発現する組換え型欠損アデノウイルス
Document Type and Number:
Japanese Patent JP3422995
Kind Code:
B2
Abstract:
New recombinant nucleic acid (I) comprises (1) a genomic sequence from defective adenovirus lacking sequences necessary for its replication but retaining genomic sequences which make possible penetration of infectable cells and all sequences required for encapsidation and (2) an insert which encodes a cytokine and is under the control of a promoter present naturally or previously inserted in the genomic sequence.
Inventors:
Haddada, Hedi
Lago, Thierry
Michele Pericord
Lago, Thierry
Michele Pericord
Application Number:
JP51632293A
Publication Date:
July 07, 2003
Filing Date:
March 16, 1993
Export Citation:
Assignee:
Center National de la Lecherche Chantifique
INSTITUT GUSTAVE ROUSSY
INSTITUT GUSTAVE ROUSSY
International Classes:
A61K35/76; A61K35/761; A61K38/00; A61K48/00; A61P35/00; C07K14/52; C12N5/10; C12N7/00; C12N7/01; C12N15/09; C12N15/19; C12N15/26; C12N15/861; C12R1/91; (IPC1-7): C12N15/09; A61K38/00; A61K48/00; A61P35/00; C12N7/00
Domestic Patent References:
| JP1500755A |
Other References:
ＣＯＬＬＯＱＵＥ ＩＮＳＥＲＭ（ＨＵＭＡＮ ＧＥＮＥ ＴＲＡＮＳＦＥＲ，ＩＮＴＥＲＮＡＴＩＯＮＡＬ ＷＯＲＫＳＨＯＰ），Ｖｏｌ．２１９，Ｐ．２７１−２７２（１９９１）
ＣＯＬＬＯＱＵＥ ＩＮＳＥＲＭ（ＨＵＭＡＮ ＧＥＮＥ ＴＲＡＮＳＦＥＲ，ＩＮＴＥＲＮＡＴＩＯＮＡＬ ＷＯＲＫＳＨＯＰ），ＶｏＬ．２１９，Ｐ．５１−６１（１９９１）
Ｊ．Ｖｉｒｏｌ．，Ｖｏｌ．６１，Ｎｏ．４，Ｐ．１２２６−１２３９（１９８７）
ＣＯＬＬＯＱＵＥ ＩＮＳＥＲＭ（ＨＵＭＡＮ ＧＥＮＥ ＴＲＡＮＳＦＥＲ，ＩＮＴＥＲＮＡＴＩＯＮＡＬ ＷＯＲＫＳＨＯＰ），ＶｏＬ．２１９，Ｐ．５１−６１（１９９１）
Ｊ．Ｖｉｒｏｌ．，Ｖｏｌ．６１，Ｎｏ．４，Ｐ．１２２６−１２３９（１９８７）
Attorney, Agent or Firm:
Hajime Tsukuni (2 outside)