Title:
【発明の名称】治療法および薬剤スクリーニング法
Document Type and Number:
Japanese Patent JP2003505058
Kind Code:
A
Abstract:
A method of preventing or reducing foam cell development from macrophages, or removing foam cells, in a patient, the method comprising administering to the patient an effective amount of an inhibitor of PPAR delta activity. A method of preventing or treating a vascular disease associated with plaque formation and/or thrombotic blockage of the blood vessels in a patient, the method comprising administering to the patient an effective amount of an inhibitor of PPAR delta activity.
Inventors:
Colin Neil Alexander Palmer
Helen Bosper
Charles Roland Wolf
Helen Bosper
Charles Roland Wolf
Application Number:
JP2001511949A
Publication Date:
February 12, 2003
Filing Date:
July 19, 2000
Export Citation:
Assignee:
THE UNIVERSITY OF DUNDEE
International Classes:
A61K31/00; A61K31/4439; A61K31/711; A61K38/17; A61K45/00; A61K48/00; A61P9/00; A61P9/10; A61P25/28; A61P29/00; A61P35/00; A61P43/00; C12N15/09; G01N33/50; C12N15/113; C12Q1/02; G01N33/15; A61K38/00; C12R1/91; (IPC1-7): C12N15/09; A61K31/711; A61K45/00; A61K48/00; A61P9/00; A61P9/10; A61P25/28; A61P35/00; A61P43/00; C12Q1/02; G01N33/15; G01N33/50
Domestic Patent References:
| JPH0597679A | 1993-04-20 | |||
| JPH11506114A | 1999-06-02 |
Foreign References:
| WO1998008836A1 | 1998-03-05 | |||
| WO1999000491A1 | 1999-01-07 | |||
| WO1997028149A1 | 1997-08-07 | |||
| WO1999004815A1 | 1999-02-04 | |||
| WO1998025598A2 | 1998-06-18 |
Other References:
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JPN5002012481, Ｋｒｅｙ Ｇ， ｅｔ ａｌ．, "Ｆａｔｔｙ ａｃｉｄｓ， ｅｉｃｏｓａｎｏｉｄｓ， ａｎｄ ｈｙｐｏｌｉｐｉｄｅｍｉｃ ａｇｅｎｔｓ ｉｄｅｎｔｉｆｉｅｄ ａｓ ｌｉｇａｎｄｓ ｏｆ ｐｅｒｏｘｉｓｏｍｅ ｐｒｏｌｉｆｅｒａｔｏｒ−", ＭＯＬＥＣＵＬＡＲ ＥＮＤＯＣＲＩＮＯＬＯＧＹ, 199706, Ｖｏｌ． １１， Ｎｏ． ６, ｐｐ． ７７９−７９１
JPN6010046599, Ｂｒｕｄｅ ＩＲ， ｅｔ ａｌ．, "Ｐｌａｓｍａ ｈｏｍｏｃｙｓｔｅｉｎｅ ｃｏｎｃｅｎｔｒａｔｉｏｎ ｒｅｌａｔｅｄ ｔｏ ｄｉｅｔ， ｅｎｄｏｔｈｅｌｉａｌ ｆｕｎｃｔｉｏｎ ａｎｄ ｍｏｎｏｎｕｃｌｅａｒ ｃｅｌｌ ｇｅｎｅ ｅｘ", Ｅｕｒｏｐｅａｎ Ｊｏｕｒｎａｌ ｏｆ Ｃｌｉｎｉｃａｌ Ｉｎｖｅｓｔｉｇａｔｉｏｎ, 199902, Ｖｏｌ． ２９， Ｎｏ． ２, ｐｐ． １００−１０８
JPN6010046600, Ｇｉｍｂｌｅ ＪＭ， ｅｔ ａｌ．, "Ｅｘｐｒｅｓｓｉｏｎ ｏｆ Ｐｅｒｏｘｉｓｏｍｅ Ｐｒｏｌｉｆｅｒａｔｏｒ Ａｃｔｉｖａｔｅｄ Ｒｅｃｅｐｔｏｒ ｍＲＮＡ ｉｎ Ｎｏｒｍａｌ ａｎｄ Ｔｕｍｏｒｉｇｅｎｉｃ Ｒｏｄｅｎｔ Ｍａｍｍａ", Ｂｉｏｃｈｅｍｉｃａｌ ａｎｄ Ｂｉｏｐｈｙｓｉｃａｌ Ｒｅｓｅａｒｃｈ Ｃｏｍｍｕｎｉｃａｔｉｏｎｓ, 19981230, Ｖｏｌ． ２５３， Ｎｏ． ３, ｐｐ． ８１３−８１７
JPN6010046601, Ｆｏｒｍａｎ ＢＭ， ｅｔ ａｌ．, "Ｈｙｐｏｌｉｐｉｄｅｍｉｃ ｄｒｕｇｓ， ｐｏｌｙｕｎｓａｔｕｒａｔｅｄ ｆａｔｔｙ ａｃｉｄｓ， ａｎｄ ｅｉｃｏｓａｎｏｉｄｓ ａｒｅ ｌｉｇａｎｄｓ ｆｏｒ ｐｅｒｏｘｉｓｏｍｅ ｐｒｏｌｉｆｅ", Ｐｒｏｃｅｅｄｉｎｇｓ ｏｆ ｔｈｅ Ｎａｔｉｏｎａｌ Ａｃａｄｅｍｙ ｏｆ Ｓｃｉｅｎｃｅｓ ｏｆ ｔｈｅ Ｕｎｉｔｅｄ Ｓｔａｔｅｓ ｏｆ Ａｍｅｒｉｃａ, 199704, Ｖｏｌ． ９４， Ｎｏ． ９, ｐｐ． ４３１２−４３１７
JPN6010046603, Ａｕｂｅｒｔ Ｊ， ｅｔ ａｌ．, "Ｕｐ−Ｒｅｇｕｌａｔｉｏｎ ｏｆ ＵＣＰ−２ Ｇｅｎｅ Ｅｘｐｒｅｓｓｉｏｎ ｂｙ ＰＰＡＲ Ａｇｏｎｉｓｔｓ ｉｎ Ｐｒｅａｄｉｐｏｓｅ ａｎｄ Ａｄｉｐｏｓｅ Ｃｅｌｌｓ", Ｂｉｏｃｈｅｍｉｃａｌ ａｎｄ Ｂｉｏｐｈｙｓｉｃａｌ Ｒｅｓｅａｒｃｈ Ｃｏｍｍｕｎｉｃａｔｉｏｎｓ, 19970918, Ｖｏｌ． ２３８， Ｎｏ． ２, ｐｐ． ６０６−６１１
JPN5002012481, Ｋｒｅｙ Ｇ， ｅｔ ａｌ．, "Ｆａｔｔｙ ａｃｉｄｓ， ｅｉｃｏｓａｎｏｉｄｓ， ａｎｄ ｈｙｐｏｌｉｐｉｄｅｍｉｃ ａｇｅｎｔｓ ｉｄｅｎｔｉｆｉｅｄ ａｓ ｌｉｇａｎｄｓ ｏｆ ｐｅｒｏｘｉｓｏｍｅ ｐｒｏｌｉｆｅｒａｔｏｒ−", ＭＯＬＥＣＵＬＡＲ ＥＮＤＯＣＲＩＮＯＬＯＧＹ, 199706, Ｖｏｌ． １１， Ｎｏ． ６, ｐｐ． ７７９−７９１
JPN6010046599, Ｂｒｕｄｅ ＩＲ， ｅｔ ａｌ．, "Ｐｌａｓｍａ ｈｏｍｏｃｙｓｔｅｉｎｅ ｃｏｎｃｅｎｔｒａｔｉｏｎ ｒｅｌａｔｅｄ ｔｏ ｄｉｅｔ， ｅｎｄｏｔｈｅｌｉａｌ ｆｕｎｃｔｉｏｎ ａｎｄ ｍｏｎｏｎｕｃｌｅａｒ ｃｅｌｌ ｇｅｎｅ ｅｘ", Ｅｕｒｏｐｅａｎ Ｊｏｕｒｎａｌ ｏｆ Ｃｌｉｎｉｃａｌ Ｉｎｖｅｓｔｉｇａｔｉｏｎ, 199902, Ｖｏｌ． ２９， Ｎｏ． ２, ｐｐ． １００−１０８
JPN6010046600, Ｇｉｍｂｌｅ ＪＭ， ｅｔ ａｌ．, "Ｅｘｐｒｅｓｓｉｏｎ ｏｆ Ｐｅｒｏｘｉｓｏｍｅ Ｐｒｏｌｉｆｅｒａｔｏｒ Ａｃｔｉｖａｔｅｄ Ｒｅｃｅｐｔｏｒ ｍＲＮＡ ｉｎ Ｎｏｒｍａｌ ａｎｄ Ｔｕｍｏｒｉｇｅｎｉｃ Ｒｏｄｅｎｔ Ｍａｍｍａ", Ｂｉｏｃｈｅｍｉｃａｌ ａｎｄ Ｂｉｏｐｈｙｓｉｃａｌ Ｒｅｓｅａｒｃｈ Ｃｏｍｍｕｎｉｃａｔｉｏｎｓ, 19981230, Ｖｏｌ． ２５３， Ｎｏ． ３, ｐｐ． ８１３−８１７
JPN6010046601, Ｆｏｒｍａｎ ＢＭ， ｅｔ ａｌ．, "Ｈｙｐｏｌｉｐｉｄｅｍｉｃ ｄｒｕｇｓ， ｐｏｌｙｕｎｓａｔｕｒａｔｅｄ ｆａｔｔｙ ａｃｉｄｓ， ａｎｄ ｅｉｃｏｓａｎｏｉｄｓ ａｒｅ ｌｉｇａｎｄｓ ｆｏｒ ｐｅｒｏｘｉｓｏｍｅ ｐｒｏｌｉｆｅ", Ｐｒｏｃｅｅｄｉｎｇｓ ｏｆ ｔｈｅ Ｎａｔｉｏｎａｌ Ａｃａｄｅｍｙ ｏｆ Ｓｃｉｅｎｃｅｓ ｏｆ ｔｈｅ Ｕｎｉｔｅｄ Ｓｔａｔｅｓ ｏｆ Ａｍｅｒｉｃａ, 199704, Ｖｏｌ． ９４， Ｎｏ． ９, ｐｐ． ４３１２−４３１７
JPN6010046603, Ａｕｂｅｒｔ Ｊ， ｅｔ ａｌ．, "Ｕｐ−Ｒｅｇｕｌａｔｉｏｎ ｏｆ ＵＣＰ−２ Ｇｅｎｅ Ｅｘｐｒｅｓｓｉｏｎ ｂｙ ＰＰＡＲ Ａｇｏｎｉｓｔｓ ｉｎ Ｐｒｅａｄｉｐｏｓｅ ａｎｄ Ａｄｉｐｏｓｅ Ｃｅｌｌｓ", Ｂｉｏｃｈｅｍｉｃａｌ ａｎｄ Ｂｉｏｐｈｙｓｉｃａｌ Ｒｅｓｅａｒｃｈ Ｃｏｍｍｕｎｉｃａｔｉｏｎｓ, 19970918, Ｖｏｌ． ２３８， Ｎｏ． ２, ｐｐ． ６０６−６１１
Attorney, Agent or Firm:
Aoyama Ryo (2 outside people)