Title:
【発明の名称】シス作用性核酸エレメントおよび使用法
Document Type and Number:
Japanese Patent JP2002520074
Kind Code:
A
Abstract:
The invention provides a method of identifying nucleic acid molecules that contain cis acting nucleic acid elements. Also provided is a method of isolating nucleic acid binding factors. The invention also provides methods of identifying compounds that are cis acting nucleic acid element analogs, compounds that are nucleic acid binding factor analogs, compounds that selectively bind cis acting nucleic acid elements and compounds that selectively displace binding between a nucleic acid binding factor and a cis acting nucleic acid element or between nucleic acid binding factors. Also provided is a method of determining a binding state of a nucleic acid. Pluralities of isolated nucleic acid molecules containing cis acting nucleic acid elements, of isolated cis acting nucleic acid elements and of isolated nucleic acid binding factors are also provided. The invention further provides methods of treating pathological conditions using molecules of the invention to alter genetic activities of nucleic acids involved in pathological conditions.
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Inventors:
Stuart A. Kaufman
Marc Barive
Marc Barive
Application Number:
JP2000560292A
Publication Date:
July 09, 2002
Filing Date:
July 13, 1999
Export Citation:
Assignee:
System Molecular Corporation
International Classes:
C12N15/10; C12Q1/68; C12N15/09; (IPC1-7): C12N15/09; C12Q1/68
Attorney, Agent or Firm:
Aoyama Ryo (1 person outside)