Title:
【発明の名称】遺伝子導入産物に機能的寛容を誘導する方法
Document Type and Number:
Japanese Patent JP2003531816
Kind Code:
A
Abstract:
Methods of inducing functional tolerance for the expression products of transgenes in somatic cells are disclosed, which methods comprise the introduction into the recipient of stem cells, such as hematopoietic stem cells, transgenically modified so as to express one or more neoantigens, such procedure optionally preceded by a myeloreductive procedure. The purpose of the disclosed methods is to induce tolerance to these same antigens when later expressed by cells or vectors to be introduced as part of a gene therapy treatment.
Inventors:
Anderson, Golan, Kay.
Application Number:
JP2001528553A
Publication Date:
October 28, 2003
Filing Date:
September 29, 2000
Export Citation:
Assignee:
Biotransplant, Incorporated
International Classes:
C12N15/09; A61K31/52; A61K31/573; A61K35/28; A61K35/44; A61K39/00; A61K39/395; A61K48/00; A61P3/00; A61P3/06; A61P7/00; A61P7/04; A61P11/00; A61P21/04; A61P35/00; A61P37/02; C12N5/10; A61K35/12; (IPC1-7): A61K48/00; A61K31/52; A61K31/573; A61K35/28; A61K35/44; A61K39/395; A61P3/00; A61P3/06; A61P7/00; A61P7/04; A61P11/00; A61P21/04; A61P35/00; A61P37/02
Attorney, Agent or Firm:
Hiroyuki Niwa