Title:
改善されたバイオアナリシス特性およびバイオプロセシング特性のための、治療用免疫グロブリンＧ４の設計
Document Type and Number:
Japanese Patent JP7062669
Kind Code:
B2
Abstract:
In certain embodiments, the disclosure provides an IgG4 antibody comprising a heavy chain and a light chain, wherein the heavy chain comprises: (a) a modified IgG4 CH1 region having a substitution of the lysine residue at position 196; or (b) a modified IgG4 hinge region having a substitution of the serine residue at position 217, the glycine residue at position 220, the proline residue at position 224 or the proline residue at position 225. Preferably, the IgG4 antibody further comprises a substitution of the serine residue at position 228 in the heavy chain hinge region.
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Inventors:
Chiang Yu Min
Jenjiang Li
Xuan Quo Shu
Tan Jijoong
Chao Juan
Ji Chang Chen
Jenjiang Li
Xuan Quo Shu
Tan Jijoong
Chao Juan
Ji Chang Chen
Application Number:
JP2019534111A
Publication Date:
May 06, 2022
Filing Date:
December 22, 2017
Export Citation:
Assignee:
BRISTOL-MYERS SQUIBB COMPANY
International Classes:
C12N15/13; A61K39/395; A61K47/68; A61P29/00; A61P35/00; A61P37/02; C07K16/18; C07K16/28; C07K16/46; C07K19/00; C12N5/10; C12N15/62; C12N15/63; C12P21/02; C12P21/08
Domestic Patent References:
| JP2015513537A | ||||
| JP2013538052A |
Foreign References:
| WO2009041613A1 |
Other References:
Journal of Chromatography A ,2015年11月05日,Vol.1424 ,p92-101
Attorney, Agent or Firm:
Yamato Kento
Norifumi Tomita
Fumio Inai
Manami Sasakura
Norifumi Tomita
Fumio Inai
Manami Sasakura
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